Novel detergent compositions with enhanced depositing, conditioning and softness capabilities

ABSTRACT

Novel “two-in-one” detergent compositions comprised of at least one water soluble silicone agent, at least one cationic conditioning agent, and a detergent. These compositions are suitable for use in shampoos, baths, and shower gels. Also described is a novel delivery system for depositing benefit agents into and onto the skin, nails, and/or hair comprised of at least one water soluble silicone and at least one cationic conditioning agent.

BACKGROUND OF THE INVENTION

[0001] 1. Field of Invention

[0002] The present invention relates to detergent compositions that notonly effectively cleanse the hair but also impart superior wet stage anddry stage conditioning properties to the hair in a single application.The present invention is further directed to a novel delivery system fordelivering benefit agents onto and/or into the surface of the skin,nails, and/or hair, and methods of using such systems.

[0003] 2. Background of the Invention and Prior Art

[0004] Consumers often desire to have a hair shampoo that not onlyeffectively cleanses the hair, but that also imparts other desirableproperties, such as conditioning and lathering, to the hair. Becausenonionic, amphoteric and zwitterionic surfactants are relativelyinferior cleansing surfactants in comparison to anionic surfactants,hair shampoos generally are formulated with the latter, which thoroughlycleanses as opposed to conditions the hair. Hence, hair that has beenshampooed with an anionic surfactant-based composition usually appearsunconditioned and is considered to be cosmetically unappealing.Furthermore, anionic surfactants adversely leave the hair with anundesirable harsh and “dry to the touch” feel, which is difficult tocomb in either the wet or dry state. Even after complete drying, suchthoroughly cleansed hair remains unsatisfactory in hair softness and“flyaway” properties. Thus, it is usually necessary to perform apost-shampoo conditioning step to such hair in order to ameliorate theseundesirable physical characteristics.

[0005] With the advent of so-called “two-in-one” conditioning shampoos,it became possible to condition and cleanse hair simultaneously.However, it is well known that the formulation of such “two-in-one”conditioning shampoos is difficult due to the inherent incompatibilitybetween the cleansing anionic surfactants and the cationic conditioningagents. Unfortunately, those known “two-in-one” conditioning shampoosthat have overcome the incompatibility problem disadvantageously possessinferior cleansing and conditioning properties.

[0006] One known method for reducing the incompatibility between theanionic surfactants and the cationic conditioning agents is through theuse of alternative, non-anionic surfactants and improved cationicconditioning agents. However, such alternative, non-anionic surfactantspossess relatively inferior cleansing properties.

[0007] Other efforts have concentrated on varying the types ofconditioners. Cationic conditioning agents disadvantageously do notgenerally provide optimal overall conditioning benefits, particularly inthe areas of “softness” and “wet/dry combing”, when delivered as aningredient in a shampoo composition. Water-insoluble conditioningagents, such as the non-volatile silicones that are well recognized inthe art as providing a degree of softness to the hair, often results inunstable “two-in-one” formulations. See U.S. Pat. No. 4,704,272; U.S.Pat. No. 4,741,855; and U.S. Patent RE 34,584. Substantive cationicpolymers, which are capable of depositing on the hair shaft duringshampooing to impart the desired degree of manageability,disadvantageously result in formulations that give the hair a greasyfeeling or “build-up” on hair. See U.S. Pat. No. 5,221,530; U.S. Pat.No. 5,417,965; U.S. Pat. No. 4,292,212; and U.S. Pat. No. 4,472,297.

[0008] Another important property of cleansing compositions that isdesired by consumers is lathering. Consumers often associate highlathering with effective cleansing, and typically prefer high latheringshampoos to low lathering shampoos from an aesthetic standpoint.Unfortunately, many therapeutic shampoos, in particular those possessingtherapeutic agents such as anti-dandruff agents, contain active agentsthat tend to adversely affect lathering performance. It is well knownthat the deposition of therapeutic agents on the hair or skin may beimproved via significantly increasing the levels of therapeutic agentsin the shampoo compositions. However, not only does the use of such highlevels therapeutic agents disadvantageously increase raw materialscosts, but also it also reduces the latherability of the shampoo anddeleteriously affects product stability. The presence of detergents inthe anti-dandruff shampoos also interferes with the ability oftherapeutic agents to deposit onto the hair because the detergents aredesigned to carry or remove oil, grease, dirt, and particulate matterfrom the hair and scalp during rinsing.

[0009] Accordingly, it would be highly desirable to find a “two-in-one”cleansing composition capable of effectively cleansing and detanglingthe hair while imparting superior wet and dry combing and softnessthereto, without creating “build-up”. It would also be desirable to havea high-lathering “two-in-one” cleansing composition that not onlyeffectively cleansed the hair but also deposited a significant amount oftherapeutic agents onto the hair and skin.

SUMMARY OF THE INVENTION

[0010] In accordance with this invention, there is provided a cleansingcomposition comprising, consisting essentially of, and/or consisting of:

[0011] a) at least one water soluble silicone agent;

[0012] b) at least one cationic conditioning agent; and

[0013] c) at least one detergent.

[0014] Another embodiment of the present invention is directed to adelivery system for delivering benefit agents into and/or onto the hair,nails, and scalp comprised of, consisting essentially of, and/orconsisting of:

[0015] a) at least one water soluble silicone agent; and

[0016] b) at least one cationic conditioning agent.

[0017] Another embodiment of the present invention is directed to amethod for enhancing the deposition of benefit agents which comprises,consists essentially of, and/or consists of topically administering to ahuman or animal a composition comprised of, consists essentially of,and/or consists of:

[0018] a) a delivery system comprised of

[0019] i) at least two cationic conditioning compounds selected from thegroup consisting of guar hydroxypropyltrimonium chloride,acrylaminopropyltrimonium chloride/acrylamide copolymer, and mixturesthereof;

[0020] ii) at least one water soluble silicone compound comprised ofsilicone quaternium-13; and

[0021] b) an effective amount of a benefit agent to a desired locationon the skin, hair, and/or nails.

[0022] Yet another embodiment is directed to a method for depositing athin coating of conditioner on a hair fiber, comprised of, consistingessentially of, and/or consisting of:

[0023] a) topically applying an effective amount of a delivery systemcomposition comprised of

[0024] i) at least two cationic conditioning compounds selected from thegroup consisting of guar hydroxypropyltrimonium chloride,acrylaminopropyltrimonium chloride/acrylamide copolymer, and mixturesthereof;

[0025] ii) at least one water soluble silicone compound comprised ofcetyl triethylmonium dimethicone copolyol phthalate; and

[0026] iii) a hydrophilic benefit agent

[0027] to a desired location on the hair of a human or animal.

[0028] Yet another embodiment is directed to a method for treating hairloss comprising, consisting essentially of, and/or consisting oftopically administering to a human or animal at a desired area fortreating hair loss a composition comprised of, consisting essentiallyof, and/or consisting of based upon the total weight of the composition:

[0029] A. a delivery system comprised of

[0030] i.) at least one water soluble silicone agent;

[0031] ii) at least one cationic conditioning agent; and

[0032] B. an effective amount of a hair loss treatment agent.

[0033] Another embodiment is directed to a method for inhibiting hairgrowth comprising, consisting essentially of, and/or consisting oftopically administering to a human or animal at a desired area forinhibiting hair growth a composition comprised of, consistingessentially of, and/or consisting of, based upon the total weight of thecomposition,:

[0034] A. a delivery system comprised of

[0035] i.) at least one water soluble silicone agent;

[0036] ii) at least one cationic conditioning agent; and

[0037] B. an effective amount of a hair growth inhibiting agent.

[0038] Another embodiment of the present invention is directed to amethod for treating or minimizing the effects of aging comprising,consisting essentially of, and/or consisting of topically administeringto a human or animal at a desired area a composition comprised of,consisting essentially of, and/or consisting of based upon the totalweight of the composition,:

[0039] A. a delivery system comprised of

[0040] i.) at least one water soluble silicone agent;

[0041] ii) at least one cationic conditioning agent; and

[0042] B. an effective amount of an anti-aging active agent.

[0043] Another embodiment of the present invention is directed to amethod for treating acne comprising, consisting essentially of, and/orconsisting of topically administering to a human or animal at a desiredarea a composition comprised of, consisting essentially of, and/orconsisting of, based upon the total weight of the composition,:

[0044] A. a delivery system comprised of

[0045] i.) at least one water soluble silicone agent;

[0046] ii) at least one cationic conditioning agent; and

[0047] B. an effective amount of an anti-acne active agent.

[0048] Another embodiment of the present invention is directed to amethod for depigmenting skin comprising, consisting essentially of,and/or consisting of topically administering to a human or animal at adesired area a composition comprised of, consisting essentially of,and/or consisting of based upon the total weight of the composition,:

[0049] A. a delivery system comprised of

[0050] i.) at least one water soluble silicone agent;

[0051] ii) at least one cationic conditioning agent; and

[0052] B. an effective amount of a depigmentation active agent.

[0053] In yet another embodiment of the present invention is a methodfor treating the diseases of dandruff, seborrheic dermatitis, andpsoriasis and/or the symptoms associated therewith comprising,consisting essentially of, and/or consisting of topically administeringto a human or animal at a desired area a composition comprised of,consisting essentially of, and/or consisting of based upon the totalweight of the composition,:

[0054] A. a delivery system comprised of

[0055] i.) at least one water soluble silicone agent;

[0056] ii) at least one cationic conditioning agent; and

[0057] B. an effective amount of a benefit agent selected from the groupconsisting of an anti-dandruff agent, an anti-seborrheic dermatitisagent, an anti-psoriasis agent, and mixtures thereof.

[0058] The composition of this invention, when used in a shampoo or bodycleanser, possesses one or more of the following properties: lathering,cleansing, wet detangling, wet combining, dry combing, conditioning,softness, manageability, rinseability, and ability to significantlydeposit therapeutic agents. Moreover, the delivery system of the presentinvention is capable of effectively depositing benefit agents intoand/or onto the skin, hair and nails.

BRIEF DESCRIPTION OF THE DRAWINGS

[0059] The above and other aspects and novel features of the presentinvention will become apparent from the following detailed descriptionof the preferred embodiments, as illustrated in the accompanying figuresshowing the improved hair conditioning properties imparted by using themethod and composition of the present invention, wherein:

[0060]FIG. 1(a) is a mass spectrometric representation of a hair fiberpreviously treated with Pantene Pro-V shampoo.

[0061]FIG. 1(b) is a mass spectrometric representation of a hair fiberpreviously treated with a cleansing composition of the present inventionas described in Example 11.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

[0062] In one embodiment of the present invention, the cleansingcomposition may suitably comprise, consist of, or consist essentiallyof: a) at least one water soluble silicone agent; b) at least onecationic conditioning agent; and c) at least one detergent. Preferably,the cleansing composition contains, based upon the total weight of thecleansing composition, a) from about 0.001 percent to about 20 percent,and preferably from about 0.01 percent to about 5 percent of watersoluble silicone agents; b) from about 0.01 percent to about 10 percent,and preferably from about 0.1 percent to about 5 percent of cationicconditioning agents; and c) from about 0.01 percent to about 30 percent,and preferably from about 5 percent to about 20 percent detergent.

[0063] The first component of the cleansing composition is a watersoluble or insoluble silicone agent, with water soluble silicone agentsbeing preferred. Examples of suitable water soluble silicone agentsnonexclusively include the water soluble dimethicones substituted withfatty acid moieties, water soluble silicone quaterniums, and mixturesthereof. Either volatile or nonvolatile water soluble silicones aresuitable for use in the present invention, with the latter beingpreferred. Preferably, the water soluble dimethicones are substitutedwith fatty acid moieties selected from fatty acids having from about 5carbon atoms to about 30 carbon atoms and the silicone quaterniumscontain about 6 carbon atoms to about 20 carbon atoms.

[0064] Examples of suitable water soluble volatile silicone agentsnonexclusively include polydimethylsiloxane, hexamethyldisiloxane,cyclomethicone fluids such as polydimethylcyclosiloxane availablecommercially from Dow Corning Corporation of Midland, Mich. under thetradename, “DC-345” and mixtures thereof, with the cyclomethicone fluidsbeing preferred.

[0065] Examples of suitable water soluble nonvolatile silicone agentsnonexclusively include cetyl triethylmonium dimethicone copolyolphthalate, stearalkonium dimethicone copolyol phthalate, dimethiconecopolyol having the following structure I.:

[0066] Wherein:

[0067] q′ is an integer from about 1 to about 7000;

[0068] q″ is an integer from about 1 to about 5000;

[0069] R₉ may be any water soluble group such as:

[0070] a) a fatty alcohol having from about 8 carbon atoms to about 30carbon atoms;

[0071] b) a fatty acid having from about 8 carbon atoms to about 30carbon atoms, and derivatives thereof;

[0072] c) a crosslinked water soluble polymer such as mercaptol propylcopolymer;

[0073] d) a cationic moiety, e.g. trimonium chloride;

[0074] e) propyl PG-Betaine;

[0075] f) polypeptides such as polysarcosine, and

[0076] e) mixtures thereof,

[0077] dimethicone copolyol acetate, dimethicone copolyol lactate,dimethicone copolyol laurate, dimethicone copolyol methyl ether,dimethicone copolyol octyl dodecyl citrate, hydrolyzed soyprotein/dimethicone copolyol acetate, dimethiconol, and mixturesthereof.

[0078] Examples of suitable water soluble silicone quaterniumsnonexclusively include silicone quaternium 13, silicone quaternium 40,quaternium 80 and mixtures thereof, as well as those siliconequaterniums disclosed in U.S. Pat. No. 5,098,979, which is incorporatedby reference herein in its entirety.

[0079] More preferred water soluble silicone agents include siliconequaternium 13, cetyl triethylmonium dimethicone copolyol phthalate,stearalkonium deimethicone copolyol phthalate, and mixtures thereof.

[0080] The second component in the composition of the present inventionis a cationic conditioning agent such as a cationic cellulosederivative; a cationic guar derivative; a homopolymer or copolymer of acabonic monomer selected from:

[0081] a. a monomer having the formula II.

[0082] wherein

[0083] R is H or CH₃,

[0084] Y is O or NH,

[0085] R₁ is an alkylene group having from about 2 to about 6 carbonatoms,

[0086] R₂, R₃ and R₄ are each independently an alkyl group orhydroxyalkyl group having from about 1 to about 22 carbon atoms, and

[0087] X is a monovalent anion selected from halide and alkyl sulfatehaving from about 1 to about 4 carbon atoms, or

[0088] b. diallyidimethylammonium chloride,

[0089] or mixtures thereof.

[0090] A suitable cationic cellulose derivative is the polymericquaternary ammonium salt derived from the reaction of hydroxyethylcellulose with a trimethylammonium substituted epoxide. The materialknown as Polyquaternium-10, commercially available from AmercholCorporation of Edison, N.J. as “Polymer JR400,” is especially useful inthis regard.

[0091] The cationic guar derivative is preferably a guarhydroxypropyltrimonium chloride, available commercially fromRhone-Poulenc Inc., of Cranbury, N.J. under the tradename, “Jaguar C-17.”

[0092] Another suitable cationic polymer includes those compoundsderived from acrylamidopropyl trimonium chloride which has the formulaIII.:

[0093] and more preferably is the copolymer of this monomer withacrylamide, the latter of which is available commercially from AlliedColloids, of Suffolk, Va. under the tradename, “Salcare SC60.”

[0094] Other suitable cationic conditioning polymers are those derivedfrom the monomer diallyldimethylammonium chloride. The homopolymer ofthis monomer is Polyquaternium-6, which is available commercially fromAllied Colloids of Suffolk, Va. under the tradename, “Salcare SC30.” Thecopolymer of diallyidimethylammonium chloride with acrylamide is knownas Polyquaternium-7, and is also available from Allied Colloids underthe tradename “Salcare SC10.” Other suitable polymers includepolyquaternium-47, which is available from Calgon Corporation under thetradename, “MERQUAT 2001N.”

[0095] Most preferred cationic conditioning agents includeacrylamidopropyltrimonium chloride/acrylamide copolymer, guarhydroxypropyltrimonium chloride, and mixtures thereof.

[0096] The third component in the composition of the present inventionis a detergent. By “detergent,” it is meant any known surfactant and/orsoap that is compatible with the silicone agents and the cationic agentsof the cleansing composition, and may nonexclusively include anionicsurfactants, nonionic surfactants, cationic surfactants, amphotericsurfactants (including betaine surfactants and zwitterionic surfactants)and mixtures thereof.

[0097] Examples of suitable anionic surfactants include, but are notlimited to, compounds in classes known as alkyl sulfates, sulfate estersof an alkylphenoxy polyoxyethylene ethanol, alpha-olefin sulfonates,betaalkyloxy alkane sulfonates, alkyl arylsulfonates, alkyl carbonates,alkyl ether carboxylates, fatty acids, sulfosuccinates, alkyl ethersulfosuccinates, sarcosinates, octoxynol phosphates, nonoxynolphosphates, taurates, fatty taurides, sulfated monoglycerides, fattyacid amido polyoxyethylene sulfates, and isethionates and mixturesthereof. Many additional surfactants are described in WO 07/26860 and inMcCUTCHEON'S DETERGENTS AND EMULSIFIERS (1989), which are bothincorporated herein by reference. These anionic surfactants aregenerally present in the composition as a neutralized salt in the formof sodium salts, potassium salts, ammonium salts, lithium salts, alkylammonium salts, or hydroxyalkyl ammonium salts. Preferred anionicsurfactants are alkyl sulfates, alkyl ether sulfates, alkyl phosphates,amino acid salts such as N-acyl-L-glutamate, α-olefin sulfonates, alkylsarcosinates, alkyl benzene sulfonates, acyl isethionates, alkylsulfosuccinates, acyl methyl taurides, and mixtures thereof, with sodiumC14-16 olefin sulfonate, ammonium lauryl sulfate, sodium tridecethsulfate, sodium laureth sulfate, disodium laureth sulfosuccinate beingmost preferred.

[0098] Examples of suitable nonionic surfactants include, but are notlimited to, those set forth in WO 07/26860, with polysorbate 20, longchain alkyl glucosides having alkyl groups containing about 8 carbonatoms to about 22 carbon atoms; coconut fatty acid monoethanolamidessuch as cocamide MEA; coconut fatty acid diethanolamides, and mixturesthereof, being most preferred. Any amount of cationic surfactants ornon-ionic surfactants employed in the detergent base are in addition tothe amount of the non-ionic surfactant or cationic surfactant,respectively, that may be included in the vesicle bilayer.

[0099] Examples of suitable cationic surfactants include, but are notlimited to, those set forth in WO 07/26860, as well as the quaternaryammonium surfactants and quaternary amine surfactants that are not onlypositively charged at the pH of the shampoo composition, which generallyis about pH 10 or lower, but also are soluble in the shampoocomposition. Preferred cationic surfactants nonexclusively include then-acylamidopropyl dimethylamine oxides such as cocamidopropylamine oxidesold commercially under the tradename “Incromine Oxide C” available fromCroda Inc. Parsippany, N.J.

[0100] Examples of suitable amphoteric surfactants include, but are notlimited to, those set forth in WO 07/26860, i.e., amphocarboxylates,alkyl betaines, amidoalkylbetaines, amidoalkylsultaines,amphophosphates, phosphobetaines, pyrophosphobetaines, carboxyalkylalkyl polyamines, and mixtures thereof. Preferred amphoteric surfactantsinclude amidoalkylbetaines such as cocamidopropyl betaine availablecommercially from Goldschmidt Chemical Corporation of Hopewell, Va.under the tradename “Tegobetaine E”; alkyl imidazoline having from about8 carbon atoms to about 18 carbon atoms in the alkyl group such asSodium Cocoamphopropionate available commercially from Mona IndustriesInc. of Paterson, N.J. under the tradename “Monateric CA-35”.

[0101] Examples of suitable soaps include fatty acids reacted withpotassium, sodium, ammonium, lithium, or a triethanol amine base to formsoaps such as, e.g., sodium cocoate or triethanolamine cocoate.

[0102] In a preferred embodiment, the detergent is comprised of amixture of, based upon the total weight of the detergent, from about 0.1percent to about 30 percent, and preferably from about 1 percent toabout 20 percent anionic surfactants, from about 0 percent to about 10percent, and preferably from about 1 percent to about 7 percent nonionicsurfactants, from about 0 percent to about 10 percent, and preferablyfrom about 0 percent to about 4 percent cationic surfactants, and fromabout 0 percent to about 15 percent, and preferably from about 1 percentto about 10 percent amphoteric surfactants.

[0103] In another preferred embodiment, the cleansing composition iscomprised of, based upon the total weight of surfactant, from about 50percent to about 99 percent, and preferably from about 80 percent toabout 95 percent, of anionic surfactants preferably selected from thegroup consisting of alkyl sulfates, alkyl ether sulfates, and mixturesthereof wherein the alkyl group has from about 8 carbon atoms to about18 carbon atoms, and from about 1 percent to about 20 percent, andpreferably from about 5 percent to about 15 percent of amphotericsurfactants, preferably cocamidopropyl betaine.

[0104] In another preferred embodiment, the cleansing composition iscomprised of, based upon the total weight of surfactant, from about 50percent to about 99 percent, and preferably from about 70 percent toabout 90 percent, of anionic surfactants, preferably those selected fromthe group consisting of sodium PEG-7 olive oil carboxylate, alkylsulfates, alkyl ether sulfates, and mixtures thereof wherein the alkylgroup has from about 8 carbon atoms to about 18 carbon atoms; from about1 percent to about 30 percent, and preferably from about 10 percent toabout 25 percent of an amphoteric surfactant preferably selected fromthe group consisting of cocamidopropyl betaine and mixtures thereof; andoptionally, from about 0 percent to about 15 percent, and preferablyfrom about 2 percent to about 10 percent of a cationic surfactant suchas cocammoniumcarbomoyl chloride.

[0105] In embodiments wherein a particulate compound, such as several ofthe anti-dandruff agents, e.g. zinc pyrithione, that tends toprecipitate out of the solution is combined with the cleansingcomposition, the surfactant is preferable employed in conjunction with asuspending agent, with the latter having the ability of suspending theparticulate compound. In those embodiments, the suspendingagent-containing cleansing composition may be made by either 1)simultaneously combining the suspending agent with the detergent, thesilicone agents, and the cationic conditioners, or preferably, 2)pre-mixing the suspending agent with the detergent component, thencombining the resulting mixture with the silicone agents and thecationic conditioners.

[0106] Examples of suitable suspending agents nonexclusively include: 1)acrylate polymers and copolymers thereof such as theAcrylates/Aminoacrylates C10-30 Alkyl PEG-20 Itaconate copolymeravailable commercially from National Starch and Chemical Corporation ofBridgewater, N.J. under the trade name “Structure Plus”; 2) fatty acylderivatives, wherein the acyl group has the structure IV:

[0107] wherein R₁₀ comprises a carbon chain having from about 7 carbonatoms to about 21 carbon atoms that is either saturated or unsaturatedand is either substituted or unsubstituted with, for example, hydroxylgroups; 3) esters of long chain fatty acids, wherein the fatty acidshave the structure V:

[0108] wherein R₁₁, is an alkyl group having from 8 carbon atoms toabout 30 carbon atoms, and R₁₂ is an alkyl group having from 8 carbonatoms to about 30 carbon atoms, such as stearyl stearate; 4) alkyldimethylamine oxides wherein the alkyl group has from about 8 carbonatoms to about 18 carbon atoms as disclosed in U.S. Pat. Re. 34,584,which is incorporated by reference herein in its entirety; 5)methylvinylether/maleic anhydride copolymer crosslinked with1,9-decadiene PolyVM/MA (PVM/MA decadiene crosspolymer) available fromInternational Specialty Products under the tradename, “Stabileze 06 &QM;” 6) cellulose derivatives such as methylcellulose, hydroxybutylmethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose,hydroxyethyl ethylcellulose, hydroxyethyl cellulose, and mixturesthereof; 7) Distearyl Phthalic Amide available from Stepan Company underthe tradename “Stepan SAB-2,” 8) Di(hydrogenated) Tallow Phthalic Amideavailable from Stepan Company under the tradename “Stepan TAB-2”; 9)primary amines having a fatty alkyl group with at least about 16 carbonatoms such as palmitate amine and stearamine; 10) polyacrylic acids suchas carbomers, which are available from B. F. Goodrich Company under thetradename, “Carbopol”; 11) polysaccharide gums such as xanthan gum; 12)colloidal clays such as benzyl dimethyl hydrogenated tallow ammoniummontmorillonite (Bentone 27); 13) colloidal silica; and 14) mixturesthereof. Examples of suitable fatty acyl derivatives include ethyleneglycol distearate, ethylene glycol monostearate, and alkanolamides suchas cocamide MEA, and mixtures thereof.

[0109] Preferred suspending agents include carbomer, hydroxyethylcellulose, methylvinylether/maleic anhydride copolymer crosslinked with1,9-decadiene PolyVM/MA (PVM/MA decadiene crosspolymer), andAcrylates/Aminoacrylates C10-30 Alkyl PEG-20 Itaconate Copolymer, withAcrylates/Aminoacrylates C10-30 Alkyl PEG-20 Itaconate Copolymer beingmost preferred.

[0110] The suspending agent is preferably used in an amount effectivefor suspending the particulate compound. Although such amount may varydependent upon, for example, the type of particulate compound selected,the viscosity of the formulation desired, and the stability of theformulation, typically the amount of suspending agent may range, basedupon the total weight of the detergent, from about 0 percent to about 5percent, and preferably from about 0.01 percent to about 1 percent.

[0111] Other optional ingredients that may be included in the cleansingcomposition nonexclusively include commercially available pearlescent oropacifying agents, thickeners, chelating agents, colorants, fragrances,preservatives, pH adjustors, conditioning agents, and mixtures thereof.

[0112] Suitable pearlescent or opacifying agents which are respectivelypresent in an amount, based upon the total weight of the composition, offrom about 0 percent to about 3 percent, preferably from about 0.25percent to about 2.5 percent, and more preferably, from about 0.5percent to about 1.5 percent. Examples of suitable pearlescent oropacifying agents include, but are not limited to mono or diesters of(a) fatty acids having from about 16 to about 22 carbon atoms and (b)either ethylene or propylene glycol; mono or diesters of (a) fatty acidshaving from about 16 to about 22 carbon atoms (b) a polyalkylene glycolof the formula X.:

HO-(JO)_(a)-H  X.

[0113] wherein

[0114] J is an alkylene group having from about 2 to about 3 carbonatoms; and

[0115] a is 2 or 3;

[0116] fatty alcohols containing from about 16 to about 22 carbon atoms;fatty esters of the formula XI:

KCOOCH₂L  XI.

[0117] wherein K and L independently contain from about 15 to about 21carbon atoms; inorganic solids insoluble in the shampoo composition, andmixtures thereof.

[0118] In a preferred embodiment, the pearlescent or opacifying agent isintroduced to the shampoo composition as a pre-formed, stabilizedaqueous dispersion, such as that commercially available from HenkelCorporation of Hoboken, N.J. under the tradename, “Euperlan PK-3000.”This material is a combination of glycol distearate (the diester ofethylene glycol and stearic acid), Laureth-4 (CH₃(CH₂)₁₀CH₂(OCH₂CH₂)₄OH)and cocamidopropyl betaine and preferably is in a weight percent ratioof from about 25 to about 30: about 3 to about 15: about 20 to about 25,respectively.

[0119] Examples of suitable chelating agents include those which arecapable of protecting and preserving the compositions of this invention.Preferably, the chelating agent is EDTA, and more preferably istetrasodium EDTA available commercially from Dow Chemical Company ofMidland, Mich. under the tradename, “Versene 100XL” and is present in anamount, based upon the total weight of the composition, from about 0 toabout 0.5 percent, and preferably from about 0.05 percent to about 0.25percent. Other suitable chelating agents include parabens such as methylparaben, propyl paraben, butyl paraben, isomethyl paraben, isopropylparaben, isobutyl paraben, sodium benzoate, iodopropynyl butylcarbamatewhich is commercially available as “Glycacil L” from Lonza, Inc., andmixtures thereof. Suitable preservatives include Quaternium-15,available commercially as “Dowicil 200” from the Dow ChemicalCorporation of Midland, Mich., and are present in the composition in anamount, based upon the total weight of the composition, from about 0 toabout 0.2 percent, and preferably from about 0.05 percent to about 0.10percent.

[0120] The above described cleansing composition may be prepared bycombining the desired components in a suitable container and mixing themunder ambient conditions in any conventional mixing means well known inthe art, such as a mechanically stirred propeller, paddle, and the like.Although the order of mixing is not critical, it is preferable topre-blend certain components, such as the fragrance and the nonionicsurfactant before adding such components into the main mixture.

[0121] The composition of this invention can be formulated in a varietyof dosage forms for topical application that include, but are notlimited to, for example, washes, baths, lotions, creams, ointments,sprays, aerosols, skin patches, soap, mousses, tonics, gels, solids(e.g. sticks) or the like which is designed to be left on the skin andnot washed shortly after application. Alternatively, the composition maybe applied to the desired area in the form of, for example, a lotion,cream, gel, soap, shampoo or the like which is designed to be rinsed offwithin a given amount of time after application.

[0122] Another preferred embodiment of the present invention is directedto a delivery system for delivering benefit agents to the hair, nails,and scalp comprised of a) at least one water soluble silicone agent; andb) at least one, and more preferably at least two cationic conditioningcompounds. Preferably, the delivery system is comprised of, based uponthe total weight of the delivery system, a) from about 0.001 percent toabout 10 percent, and preferably from about 0.01 percent to about 5percent of at least one water soluble silicone agent; and b) from about0.001 percent to about 5 percent, and preferably from about 0.01 percentto about 2 percent of at least one, and preferably at least two cationicconditioning compounds.

[0123] In embodiments wherein it is desirable to deposit hydrophilicbenefit agents, e.g. salicylic acid, alpha hydroxy acids, vitamins,proteins, and peptides, onto and/or into the skin, hair, and nails, itis preferable to apply thereto the benefit agent in the delivery systemcomposition comprised of at least two cationic conditioning compounds,which preferably are guar hydroxypropyltrimonium chloride andacrylaminopropyltrimonium chloride/acrylamide copolymer; and morepreferably with the combination of at least 2 cationic conditioningcompounds, which are preferably guar hydroxypropyltrimonium chloride andacrylaminopropyltrimonium chloride/acrylamide copolymer, and at leastone water soluble silicone compound, which preferably is a siliconequaternium-13. It is most preferable to apply the hydrophilic benefitagent in a delivery system comprised of at least 2 cationic conditioningcompounds, which preferably are guar hydroxypropyltrimonium chloride andacrylamidopropyltrimonium chloride/acrylamide copolymer, and at leasttwo water soluble silicone compounds, one of which is preferably asilicone quaternium-13.

[0124] In embodiments wherein it is desirable to deposit hydrophobicbenefit agents, i.e. elubiol, ketoconazole, retinol and derivativesthereof, onto and/or into the skin, nails, and/or hair, it is preferableto apply thereto the hydrophobic benefit agent in a delivery systemcomposition comprised of at least 2 cationic conditioning compounds,which preferably are guar hydroxypropyltrimonium chloride andacrylamiiopropyltrimonium chloride/acrylamide copolymer and at least onewater soluble silicone compound, which preferably is a siliconequaternium-13. It is more preferable to apply the hydrophobic benefitagent in a delivery system comprised of at least 2 cationic conditioningcompounds, which preferably are guar hydroxypropyltrimonium chloride andacrylamidopropyltrimonium chloride/acrylamide copolymer, and at leasttwo water soluble silicone compounds, one of which is preferably asilicone quaternium-13.

[0125] In embodiments wherein it is desirable to deposit a thin coatingof conditioner on the hair fiber, it is desirable to apply thereto acomposition comprised of at least two cationic agents and at least onewater soluble silicone, the lafter of which preferably is cetyltriethylmonium dimethicone copolyol phthalate. Suitable depositingconditioners nonexclusively include the silicone agents and cationicconditioning agents described herein as well as other knownconditioners.

[0126] In addition to combining a benefit agent along with the deliverysystem, another embodiment of the present invention is directed tocombining an optional benefit agent along with the above-describedcleansing composition. By “benefit agent,” it is mean any activeingredient that is to be delivered into and/or onto the skin at adesired location, such as a cosmetic agent or a pharmaceutical agent. By“cosmetic agent,” it is meant any ingredient that is appropriate forcosmetically treating, providing nutrients to, and/or conditioning thehair and/or skin via topical application. By “pharmaceutical agent,” itis mean any drug that is either hydrophobic or hydrophilic in nature andappropriate for topical use. As used herein “medicament agents” includethose agents capable of promoting recovery from injury and illness.

[0127] Examples of suitable benefit agents include, but are not limitedto, depigmentation agents; reflectants; thickening agents;detangling/wet combing agents; film forming polymers; humectants; aminoacid agents; antimicrobial agents; allergy inhibitors; anti-acne agents;anti-aging agents; anti-wrinkling agents, antiseptics; analgesics;antitussives; antipruritics; local anesthetics; anti-hair loss agents;hair growth promoting agents; hair growth inhibitor agents,antihistamines; antiinfectives; inflammation inhibitors; anti-emetics;anticholinergics; vasoconstrictors; vasodilators; wound healingpromoters; peptides, polypeptides and proteins; deodorants andanti-perspirants; medicament agents; skin emollients and skinmoisturizers; hair conditioners; hair softeners; hair moisturizers;vitamins; tanning agents; skin lightening agents; antifungals such asantifungals for foot preparations; depilating agents; shavingpreparations; external analgesics; perfumes; counterirritants;hemorrhoidals; insecticides; poison ivy products; poison oak products;burn products; anti-diaper rash agents; prickly heat agents; make-uppreparations; vitamins; amino acids and their derivatives; herbalextracts; retinoids; flavoids; sensates; anti-oxidants; skinconditioners; hair lighteners; chelating agents; cell turnoverenhancers; coloring agents; pigments; sunscreens and the like, andmixtures thereof. The amount of certain cleansing composition/deliverysystem compounds for the benefit agent purposes set forth below is inaddition to the amount of the same compound that may be desired for usein the cleansing composition/delivery system therefor.

[0128] Examples of suitable reflectants nonexclusively include mica,alumina, calcium silicate, glycol dioleate, glycol distearate, silica,sodium magnesium fluorosilicate, and mixtures thereof.

[0129] Examples of suitable UV absorbers include benzophenone,bornelone, butyl paba, cinnamidopropyl trimethyl ammonium chloride,disodium distyrylbiphenyl disulfonate, paba, potassium methoxycinnamate,and mixtures thereof.

[0130] Commercially available thickening agents that are capable ofimparting the appropriate viscosity to the conditioning shampoocompositions are suitable for use in this invention. If used, thethickener should be present in the shampoo compositions in an amountsufficient to raise the Brookfield viscosity of the composition to avalue of between about 500 to about 10,000 centipoise. Examples ofsuitable thickening agents nonexclusively include: mono or diesters ofpolyethylene glycol of formula VI.

HO—(CH₂CH₂O)_(z)H  VI.

[0131] wherein z is an integer from about 3 to about 200;

[0132] fatty acids containing from about 16 to about 22 carbon atoms;fatty acid esters of ethoxylated polyols; ethoxylated derivatives ofmono and diesters of fatty acids and glycerine; hydroxyalkyl cellulose;alkyl cellulose; hydroxyalkyl alkyl cellulose; and mixtures thereof.More specifically, suitable thickening agents nonexclusively includebehenalkonium chloride; cetyl alcohol, quaternium 46, PG-hydroxyethylcellulose, cocodimonium chloride, polyquaternium 6, polyquaternium 7,quaternium 18, PEG-18 glycerol oleate/cocoate, a mixture ofacrylates/spirit 50 acrylate copolymer, laureth 3 and propylene glycol,which is commercially available from Goldschmidt under the tradename“Antil 208,” a mixture of cocamidopropylbetaine and glyceryl lauratewhich is commercially available from Goldschmidt under the tradename,“Antil HS60,” a mixture of propylene glycol, PEG 55, and propyleneglycol oleate, which is commercially available from Goldschmidt underthe tradename, “Antil 414 liquid,” and mixtures thereof. Preferredthickeners include polyethylene glycol ester, and more preferablyPEG-150 distearate which is available from the Stepan Company ofNorthfield, Ill. or from Comiel, S.p.A. of Bologna, Italy under thetradename, “PEG 6000 DS”.

[0133] Suitable detangling/wet combing agents nonexclusively includedioleoylamidoethyl hydroxythylmonium methosulfate, di (soyoylethyl)hydroxyethylmonium methosulfate, hydroxyethyl behenamidopropyl dimoniumchloride, olealkonium chloride, polyquaternium 47, stearalkoniumchloride, tricetylmonium chloride, and mixtures thereof.

[0134] Suitable film forming polymers include those that, upon drying,produce a substantially continuous coating or film on the hair, skin, ornails. Nonexclusive examples of suitable film forming polymers includeacrylamidopropyl trimonium chloride/acrylamide copolymer; cornstarch/acrylamide/sodium acrylate copolymer; polyquaternium 10;polyquaternium 47; polyvinylmethyl/maleic anhydride copolymer;styrene/acrylates copolymers; and mixtures thereof.

[0135] Commercially available humectants which are capable of providingmoisturization and conditioning properties to the cleansing compositionare suitable for use in the present invention. The humectant ispreferably present in an amount of from about 0 percent to about 10percent, more preferably from about 0.5 percent to about 5 percent, andmost preferably from about 0.5 percent to about 3 percent, based on theoverall weight of the composition. Examples of suitable humectantsnonexclusively include: 1) water soluble liquid polyols selected fromthe group comprising glycerine, propylene glycol, hexylene glycol,butylene glycol, pentylene glycol, dipropylene glycol, and mixturesthereof; 2) polyalkylene glycol of the formula VII:

HO—(R″O)_(b)—H  VII.

[0136] wherein R″ is an alkylene group having from about 2 to about 4carbon atoms and b is an integer of from about 1 to about 10, such asPEG 4; 3) polyethylene glycol ether of methyl glucose of formula VIII:

CH₃—C₆H₁₀O₅—(OCH₂CH₂)_(c)—OH  VIII.

[0137] wherein c is an integer from about 5 to about 25;

[0138] 4) urea; 5) fructose; 6) glucose; 7) honey; 8) lactic acid; 9)maltose; 10) sodium glucuronate; and 11) mixtures thereof, withglycerine being the preferred humectant.

[0139] Suitable amino acid agents include amino acids derived from thehydrolysis of various proteins as well as the salts, esters, and acylderivatives thereof. Examples of such amino acid agents nonexclusivelyinclude amphoteric amino acids such as alkylamido alkylamines, i.e.stearyl acetyl glutamate, capryloyl silk amino acid, caprylol collagenamino acids; capryloyl kertain amino acids; capryloyl pea amino acids;cocodimonium hydroxypropyl silk amino acids; corn gluten amino acids;cysteine; glutamic acid; glycine; hair keratin amino acids; hair aminoacids such as aspartic acid, threonine, serine, glutamic acid, proline,glycine, alanine, half-cystine, valine, methionine, isoleucine, leucine,tyrosine, phenylalanine, cysteic acid, lysine, histidine, arginine,cysteine, tryptophan, citrulline; lysine; silk amino acids, wheat aminoacids; and mixtures thereof.

[0140] Suitable proteins include those polymers that have a long chain,i.e. at least about 10 carbon atoms, and a high molecular weight, i.e.at least about 1000, and are formed by self-condensation of amino acids.Nonexclusive examples of such proteins include collagen,deoxyribonuclease, iodized corn protein; keratin; milk protein;protease; serum protein; silk; sweet almond protein; wheat germ protein;wheat protein; wheat protein, alpha and beta helix of keratin proteins;hair proteins, such as intermediate filament proteins, high-sulfurproteins, ultrahigh-sulfur proteins, intermediate filament-associatedproteins, high-tyrosine proteins, high-glycine tyrosine proteins,tricohyalin, and mixtures thereof.

[0141] Examples of suitable vitamins nonexclusively include vitamin Bcomplex; including thiamine, nicotinic acid, biotin, pantothenic acid,choline, riboflavin, vitamin B6, vitamin B12, pyridoxine, inositol,carnitine; vitamins A,C,D,E,K and their derivatives such as vitamin Apalmitate and pro-vitamins, e.g. (i.e. panthenol (pro vitamin B5) andpanthenol triacetate) and mixtures thereof.

[0142] Examples of suitable antibacterial agents nonexclusively includebacitracin, erythromycin, neomycin, tetracycline, chlortetracycline,benzethonium chloride, phenol, and mixtures thereof.

[0143] Examples of suitable skin emollients and skin moisturizersnonexclusively include mineral oil, lanolin, vegetable oils, isostearylisostearate, glyceryi laurate, methyl gluceth 10, methyl gluceth 20chitosan, and mixtures thereof.

[0144] Examples of suitable hair conditioners nonexclusively includequaternized compounds such as behenamidopropyl PG-dimonium chloride,tricetylammonium chloride, dihydrogenated tallowamidoethylhydroxyethylmonium methosulfate, and mixtures thereof as well aslipophilic compounds like cetyl alcohol, stearyl alcohol, hydrogenatedpolydecene, and mixtures thereof.

[0145] An example of a suitable hair softener nonexclusively includessilicone compounds, such as those that are either non-volatile orvolatile and those that are water soluble or water insoluble. Examplesof suitable silicones include organo-substituted polysiloxanes, whichare either linear or cyclic polymers of monomeric silicone/oxygenmonomers and which nonexclusively include cetyl dimethicone; cetyltriethylammonium dimethicone copolyol phthalate; cyclomethicone;dimethicone copolyol; dimethicone copolyol lactate; hydrolyzed soyprotein/dimethicone copolyol acetate; silicone quaternium 13;stearalkonium dimethicone copolyol phthalate; stearamidopropyldimethicone; and mixtures thereof.

[0146] Examples of suitable hair moisturizers nonexclusively includepanthenyl ethyl ether, phytantriol, and mixtures thereof.

[0147] Examples of sunscreen agents nonexclusively include butylmethoxydibenzoylmethane, octyl methoxycinnamate, oxybenzone,octocrylene, octyl salicylate, phenylbenzimidazole sulfonic acid, ethylhydroxypropyl aminobenzoate, menthyl anthranilate, aminobenzoic acid,cinoxate, diethanolamine methoxycinnamate, glyceryl aminobenzoate,titanium dioxide, zinc oxide, oxybenzone, padimate o, red petrolatum,and mixtures thereof.

[0148] An example of a suitable tanning agent nonexclusively includesdihydroxyacetone.

[0149] Examples of skin lightening agents nonexclusively includehydroquinone, catechol and its derivatives, ascorbic acid and itsderivatives, and mixtures thereof.

[0150] Examples of suitable insecticides (including insect repellents,anti-scabies and anti-lice treatments) nonexclusively includepermethrin, pyrethrin, piperonyl butoxide, imidacloprid, N,N-diethyltoluamide, which refers to the material containing predominantly themeta isomer, i.e., N,N-diethyl-m-toluamide, which is also known as DEET;compounds of the formula IX

[0151] wherein

[0152] R₅ is a branched or unbranched alkyl group having about 1 toabout 6 carbon atoms;

[0153] R₆ is H, methyl or ethyl;

[0154] R₇ is a branched or unbranched alkyl or alkoxy group having fromabout 1 to about 8 carbon atoms; and

[0155] K is a —CN or a —COOR₈ group, wherein

[0156] R₈ is a branched or unbranched alkyl group having from about 1 toabout 6 carbon atoms,

[0157] natural or synthetic pyrethroids, whereby the natural pyrethroidsare contained in pyrethrum, the extract of the ground flowers ofChrysanthemum cineraraefolium or C coccineum; and mixtures thereof.Within the structure of Formula IX. are ethyl3-(N-butylacetamido)propionate, wherein R₇ is a CH₃ group, R₅ is ann-butyl group, R₆ is H, K is COOR₈ and R₈ is ethyl, which is availablecommercially from Merck KGaA of Darmstadt, Germany under the name,“Insect Repellent 3535.”

[0158] An example of an anti fungal for foot preparations nonexclusivelyincludes tolnaftate.

[0159] Examples of suitable depilating agents nonexclusively includecalcium thioglycolate, magnesium thioglycolate, potassium thioglycolate,strontium thioglycolate, and mixtures thereof.

[0160] Examples of suitable external analgesics and local anestheticsnonexclusively include benzocaine, dibucaine, benzyl alcohol, camphor,capsaicin, capsicum, capsicum oleoresin, juniper tar, menthol, methylnicotinate, methyl salicylate, phenol, resorcinol, turpentine oil, andmixtures thereof.

[0161] Examples of suitable antiperspirants and deodorantsnonexclusively include aluminium chlorohydrates, aluminium zirconiumchlorohydrates, and mixtures thereof.

[0162] Examples of suitable counterirritants nonexclusively includecamphor, menthol, methyl salicylate, peppermint and clove oils,ichtammol, and mixtures thereof.

[0163] An example of a suitable inflammation inhibitor nonexclusivelyincludes hydrocortisone.

[0164] Examples of suitable hemorrhoidal products nonexclusively includethe anesthetics such as benzocaine, pramoxine hydrochloride, andmixtures thereof; antiseptics such as benzethonium chloride; astringentssuch as zinc oxide, bismuth subgallate, balsam Peru, and mixturesthereof; skin protectants such as cod liver oil, vegetable oil, andmixtures thereof.

[0165] Examples of suitable make-up preparations nonexclusively includecomponents for lipstick, rouge, blush, eye liner, eyeshadow powder,mascara, face powder, and mixtures thereof.

[0166] One preferred type of benefit agent includes those therapeuticcomponents that are effective in the treatment of dandruff, seborrheicdermatitis, and psoriasis as well as the symptoms associated therewith.Examples of such suitable benefits agents nonexclusively include zincpyrithione, shale oil and derivatives thereof such as sulfonated shaleoil, selenium sulfide, sulfur; salicylic acid; coal tar;povidone-iodine, imidazoles such as ketoconazole, dichlorophenylimidazolodioxalan, which is commercially available from JanssenPharmaceutica, N.V., under the tradename, “Elubiol”, clotrimazole,itraconazole, miconazole, climbazole, tioconazole, sulconazole,butoconazole, fluconazole, miconazolenitrite and any possible stereoisomers and derivatives thereof such as anthralin; piroctone olamine(Octopirox); selenium sulfide; ciclopirox olamine; anti-psoriasis agentssuch as vitamin D analogs, e.g. calcipotriol, calcitriol, andtacaleitrol; vitamin A analogs such as esters of vitamin A, e.g. vitaminA palmitate, retinoids, retinols, and retinoic acid; corticosteroidssuch as hydrocortisone, clobetasone, butyrate, clobetasol propionate andmixtures thereof.

[0167] Most preferred benefit agents nonexclusively include sulfonatedshale oil, elubiol, 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide,finasteride, ketoconazole, salicylic acid, zinc pyrithione, coal tar,benzoyl peroxide, selenium sulfide, hydrocortisone, sulfur, menthol,pramoxine hydrochloride, tricetylammonium chloride, polyquaternium 10,panthenol, panthenol triacetate, vitamin A and derivatives thereof,vitamin B and derivatives thereof, vitamin C and derivatives thereof,vitamin D and derivatives thereof, vitamin E and derivatives thereof,vitamin K and derivatives thereof, keratin, lysine, arginine, hydrolyzedwheat proteins, hydrolyzed silk proteins, octyl methoxycinnamate,oxybenzone, minoxidil, titanium dioxide, zinc dioxide, retinol,erthromycin, tretinoin, and mixtures thereof.

[0168] The amount of benefit agent to be combined with the cleansingcomposition or the delivery system may vary depending upon, for example,the resulting benefit desired and the sensitivity of the user to thebenefit agent. Unless otherwise expressed herein, preferably the benefitagent is present in the cleansing composition or delivery system in anamount, based upon the total weight of the composition or deliverysystem, from about 0.001 percent to about 20 percent, and preferablyfrom about 0.001 percent to about 10 percent, and more preferably fromabout 0.001 percent to about 5 percent.

[0169] Another embodiment of the present invention is directed to amethod for enhancing the deposition of benefit agents which comprisestopically administering to a desired location on a human or animal thedelivery system composition as described above combined with aneffective amount of a benefit agent and an optional detergent. While thefrequency and amount of the delivery system to be applied will dependupon, for example, the type and amount of benefit agent available, theintended usage of the final composition, i.e. therapeutic versusmaintenance regimen, the amount and type of detergent present, and thesensitivity of the individual user to the delivery system, typically thedelivery system of the present invention should be topically applied toaffected body parts at regular intervals, and preferably from about 2 toabout 14 times per week. More preferably, the delivery systemcomposition is applied more frequently during the initial stages oftreatment, e.g. from about 5 to about 7 times per week until the desiredeffect is achieved, then less frequently when maintenance is desired,e.g. from about 2 to about 5 times per week.

[0170] In a preferred embodiment wherein the delivery system compositioncontaining a benefit agent is incorporated into a shampoo, the shampoois applied to wet hair, then the hair is washed in accordance with knownpractices. More preferably, the composition remains on the hair forgreater than about 0 to about 10 minutes, and preferably from about 1 toabout 5 minutes before rinsing.

[0171] An alternative preferred embodiment of the present invention isdirected to a method for treating hair loss, such as hair loss resultingfrom alopecia, comprising topically applying the above-describeddelivery system composition, the hair loss benefit agent, and theoptional detergent, to a desired location on an animal or human, whereinthe benefit agent is comprised of an effective amount of a hair losstreatment agent such as minoxidil or mixture thereof. As used herein,“hair loss treatment agents” shall include agents capable of growinghair and/or agents capable of preventing the loss of hair. By “effectiveamount,” it is meant an amount effective for treating hair loss andpreferably may range from, based upon the total weight of the cleansingcomposition/delivery system, from about 0.001 percent to about 20percent, and preferably from about 1 percent to about 5 percent.

[0172] Examples of benefit agents suitable for treating hair lossinclude, but are not limited to potassium channel openers or peripheralvasodilators such as minoxidil, diazoxide, and compounds such asN*-cyano-N-(tert-pentyl)-N′-3-pyridinyl-guanidine (“P-1075”) asdisclosed in U.S. Pat. No.: 5,244,664, which is incorporated herein byreference; vitamins, such as vitamin E and vitamin C, and derivativesthereof such as vitamin E acetate and vitamin C palmitate; hormones,such as erythropoietin, prostaglandins, such as prostaglandin EI andprostaglandin F2-alpha; fatty acids, such as oleic acid; diruretics suchas spironolactone; heat shock proteins (“HSP”), such as HSP 27 and HSP72; calcium channel blockers, such as verapamil HCL, nifedipine, anddiltiazemamiloride; immunosuppressant drugs, such as cyclosporin andFk-506; 5 alpha-reductase inhibitors such as finasteride; growth factorssuch as, EGF, IGF and FGF; transforming growth factor beta; tumornecrosis factor; non-steroidal anti-inflammatory agents such asbenoxaprofen; retinoids such as tretinoin; cytokines, such as IL-6, IL-1alpha, and IL-1 beta; cell adhesion molecules such as ICAM;glucorcorticoids such as betametasone; botanical extracts such as aloe,clove, ginseng, rehmannia, swertia, sweet orange, zanthoxylum, Serenoarepens (saw palmetto), Hypoxis rooperi, stinging nettle, pumpkin seeds,and rye pollen; other botanical extracts including sandlewood, red beetroot, chrysanthemum, rosemary, burdock root and other hair growthpromoter activators which are disclosed in DE 4330597 which isincorporated by reference in its entirety herein; homeopathic agentssuch as Kalium Phosphoricum D2, Azadirachta indica D2, and Joborandi DI;genes for cytokines, growth factors, and male-pattered baldness;antifungals such as ketoconazole and elubiol; antibiotics such asstreptomycin; proteins inhibitors such as cycloheximide; acetazolamide;benoxaprofen; cortisone; diltiazem; hexachlorobenzene; hydantoin;nifedipine; penicillamine; phenothaiazines; pinacidil; psoralens,verapamil; zidovudine; alpha-glucosylated rutin having at least one ofthe following rutins: quercetin, isoquercitrin, hespeddin, naringin, andmethylhesperidin, and flavonoids and transglycosidated derivativesthereof which are all disclosed in JP 7002677, which is incorporated byreference in its entirety herein; and mixtures thereof.

[0173] Preferred hair loss treatment agents include6-(1-piperdinyl)-2,4-pyrimidinediamine-3-oxide,N′-cyano-N-(tert-pentyl)-N′-3-pyridinyl-guanidine, finasteride,retinoids and derivatives thereof, ketoconazole, elubiol or mixturesthereof.

[0174] Another embodiment of the present invention is directed to amethod for inhibiting hair growth comprising topically applying theabove-described delivery system composition combined with a benefitagent and an optional detergent, to a desired area on an animal or humanfor inhibiting hair growth, wherein the benefit agent is comprised of aneffective amount of a hair growth inhibiting agent. In a preferredembodiment, the delivery system composition contains, based upon thetotal weight of the composition, from about 0.001 percent to about 20percent, and preferably from about 0.01 percent to about 5 percent hairgrowth inhibiting agent.

[0175] Examples of benefit agents suitable for use in inhibiting hairgrowth include: serine proteases such as trypsin; vitamins such asalpha-tocophenol (vitamin E) and derivatives thereof such as tocophenolacetate and tocophenol palmitate; antineoplastic agents, such asdoxorubicin, cyclophosphamide, chlormethine, methotrexate, fluorouracil,vincristine, daunorubicin, bleomycin and hydroxycarbamide;anticoagulants, such as heparin, heparinoids, coumaerins, detran andindandiones; antithyroid drugs, such as iodine, thiouracils andcarbimazole; lithium and lithium carbonate; interferons, such asinterferon alpha, interferon alpha-2a and interferon alpha-2b;retinoids, such as retinol (vitamin A), isotretinoin: glucocorticoidssuch as betamethasone, and dexamethosone; antihyperlipidaemic drugs,such as triparanol and clofibrate; thallium; mercury; albendazole;allopurinol; amiodarone; amphetamines; androgens; bromocriptine;butyrophenones; carbamazepine; cholestyramine; cimetidine; clofibrate;danazol; desipramine; dixyrazine; ethambutol; etionamide; fluoxetine;gentamicin, gold salts; hydantoins; ibuprofen; impramine;immunoglobulins; indandiones; indomethacin; intraconazole; levadopa;maprotiline; methysergide; metoprolol; metyrapone; nadolol; nicotinicacid; potassium thiocyanate; propranolol; pyridostimine; salicylates;sulfasalazine; terfenadine; thiamphenicol; thiouracils; trimethadione;troparanol; valproic acid; and mixtures thereof.

[0176] Preferred hair growth inhibitory agents include serene proteases,retinol, isotretinoin, betamethoisone, alpha-tocophenol and derivativesthereof, or mixtures thereof.

[0177] Another preferred embodiment of the present invention is directedto a method for treating acne and for reducing the signs of aging, i.e.wrinkles, fine lines, and other manifestations of photodamage,comprising topically applying the above-described delivery systemcomposition, the relevant benefit agent, and the optional detergent tothe skin of an animal or human at a desired area, wherein the benefitagent is comprised of an effective amount of an anti-acne agent or ananti-aging agent, respectively.

[0178] Examples of suitable anti-aging agents include, but are notlimited to inorganic sunscreens such as titanium dioxide and zinc oxide;organic sunscreens such as octyl-methyl cinnamates and derivativesthereof; retinoids; vitamins such as vitamin E, vitamin A, vitamin C,vitamin B, and derivatives thereof such as vitamin E acetate, vitamin Cpalmitate, and the like; antioxidants including beta carotene, alphahydroxy acid such as glycolic acid, citric acid, lactic acid, malicacid, mandelic acid, ascorbic acid, alpha-hydroxybutyric acid,alpha-hydroxyisobutyric acid, alpha-hydroxyisocaproic acid, atrrolacticacid, alpha-hydroxyisovaleric acid, ethyl pyruvate, galacturonic acid,glucopehtonic acid, glucopheptono 1,4-lactone, gluconic acid,gluconolactone, glucuronic acid, glucurronolactone, glycolic acid,isopropyl pyruvate, methyl pyruvate, mucic acid, pyruvia acid, saccharicacid, saccaric acid 1,4-lactone, tartaric acid, and tartronic acid; betahydroxy acids such as beta-hydroxybutyric acid, beta-phenyl-lactic acid,beta-phenylpyruvic acid; botanical extracts such as green tea, soy, milkthistle, algae, aloe, angelica, bitter orange, coffee, goldthread,grapefruit, hoellen, honeysuckle, Job's tears, lithospermum, mulberry,peony, puerarua, nice, safflower, and mixtures thereof.

[0179] Preferred anti-aging agents include retinoids, anti-oxidants,alpha-hydroxy acids and beta-hydroxy acid with retinol and tretinoinbeing most preferred.

[0180] Suitable amounts of anti-aging agents include, based upon thetotal weight of the delivery system composition and optional detergent,from about 0.01 percent to about 10 percent, and preferably from about0.04 percent to about 5 percent.

[0181] Examples of suitable anti-acne agents include, but are notlimited to topical retinoids (tretinoin, isotretinoin, motretinide,adapalene, tazarotene, azelaic acid, retinol); salicylic acid; benzoylperoxide; resorcinol; antibiotics such as tetracycline and isomersthereof, erythromycin, and the anti-inflammatory agents such asibuprofen, naproxen, hetprofen; botanical extracts such as alnus,arnica, artemisia capillaris, asiasarum root, birth, calendula,chamomile, cnidium, comfrey, fennel, galla rhois, hawthrom, houttuynia,hypericum, jujube, kiwi, licorice, magnolia, olive, peppermint,philodendron, salvia, sasa albo-marginata; imidazoles such asketoconazole and elubiol, and those described in Gollnick, H et al.196(1) Dermatology Sebaceous Glands, Acne and Related Disorders, 119-157(1998), which is incorporated by reference herein, and mixtures thereof.

[0182] Preferred anti-acne agents include benzoyl peroxide, retinol,elubiol, antibiotics, and salicylic acid, with retinol and tretinoinbeing most preferred.

[0183] Suitable amount of anti-acne agents include, based upon the totalweight of the delivery system composition and optional detergent, fromabout 0.01 percent to about 10 percent, and preferably from about 0.04percent to about 5 percent.

[0184] Another preferred embodiment of the present invention is directedto a method for depigmenting the skin comprising topically applying toskin at a desired area the above-described delivery system composition,the optional detergent, and an effective amount of the depigmentationbenefit agent. Suitable effective amounts of depigmentation agentsinclude, based upon the total weight of the delivery system, from about0.01 percent to about 10 percent, and preferably from about 0.04 percentto about 5 percent.

[0185] Examples of suitable depigmentation agents include, but are notlimited to retinoids such as retinol; Kojic acid and its derivativessuch as, for example, kojic dipalmitate; hydroquinone and it derivativessuch as arbutin; transexamic acid; vitamins such as niacin, vitamin Cand its derivatives; azelaic acid; placertia; licorice; extracts such aschamomile and green tea, and mixtures thereof, with retinol, Kojic acid,and hydroquinone, being preferred.

[0186] An alternative preferred embodiment of the present invention isdirected to a method for treating the symptoms and/or the diseases ofdandruff, seborrheic dermatitis and/or psoriasis, comprising topicallyapplying the above-described delivery system composition, the benefitagent, and the optional detergent, to a location desired wherein thebenefit agent is comprised of an effective amount of a dandrufftreatment agent, a seborrheic dermatitis treatment agent, or a psoriasistreatment agent, respectively. As used herein, “dandruff treatmentagent,” “seborrheic dermatitis treatment agent,” or a “psoriasistreatment agent,” respectively, shall include agents capable of treatingthe symptoms and/or the diseases of dandruff, seborrheic dermatitis, andpsoriasis, respectively. By “effective amount,” it is meant an amounteffective for treating the disease and/or the symptoms associatedtherewith and preferably may range from, based upon the total weight ofthe vesicle delivery system and optional detergent, from about 0.001percent to about 10 percent, and preferably from about 0.01 percent toabout 5 percent.

[0187] Examples of benefit agents suitable for treating the symptomsand/or the diseases of dandruff, seborrheic dermatitis and/or psoriasis,respectively, nonexclusively include those set forth above with shaleoil and derivatives thereof, elubiol, ketoconazole, coal tar, salicylicacid, zinc pyrithione, selenium sulfide, hydrocortisone, sulfur,menthol, pramoxine hydrochloride, and mixtures thereof beingparticularly preferred.

[0188] We have unexpectedly found that the above-described cleansingcomposition/delivery system is capable of efficiently mediating thedeposition and permeation of various benefit agents, such asantidandruff agents, onto and into the skin following topicaladministration thereto.

[0189] We have surprisingly found that the cleansing composition of thepresent invention is sufficiently stable to resist phase separation eventhough both an anionic surfactant and cationic components may be presentin the composition. Furthermore, the cleansing composition not onlyeffectively cleanses the hair due to the ability to include an anionicsurfactant therein, but it also effectively deposits conditioning agentson the hair without exhibiting an excessive build-up thereon, even afterrepeated shampooing. Consequently, the hair is left in a moremanageable, softer, shiny and overall more esthetically pleasing stateafter only a single application of the composition to the hair.

[0190] We have further unexpectedly found that the above-describeddelivery system is capable of efficiently mediating the deposition andpermeation of various benefit agents, such as antidandruff agents, ontoand into the skin, hair, and nails, following topical administrationthereto.

[0191] The invention illustratively disclosed herein suitably may bepracticed in the absence of any component, ingredient, or step which isnot specifically disclosed herein. Several examples are set forth belowto further illustrate the nature of the invention and the manner ofcarrying it out. However, the invention should not be considered asbeing limited to the details thereof.

EXAMPLES Example 1 Preparation of Cleansing Shampoo containing TwoCationic Agents

[0192] Shampoos comprised of the following components as set forth inTable 1 were prepared: TABLE 1 Cleansing shampoo with two cationicdepositing enhancing agents. Trade Name CTFA % wt/wt Supplier 1 DI WaterDI Water 72.965 2 Salcare SC 60 Acrylamidopropylltrimoniumchloride 0.08Ciba Specialties Acrylamide Copolymer 3 Jaguar C 17 Guar HydroxypropylTrimonium 0.15 Rhone-Poulenc Chloride 4 Citric Acid Anh Citric Acid0.025 Roche 5 Elubiol Dichlorophenyl Imidazoldioxolan 0.50 JanssenPharm. 6 Salicylic Acid Salicylic Acid 1.00 Rhone-Poulenc 7 Cutina AGSGlycol Distearate 1.75 Henkel 8 Methl Paraben Methyl Paraben 0.20 NipaHardwicke Inc. 9 Empicol EAC 70 Ammonium Laureth Sulfate 3.6 Albright &Wilson 10 Empicol AL 70 Ammonium Lauryl Sulfate 11.8 Albright & Wilson11 Tego Betaine E Cocamidopropyl Betaine 2.43 Goldschmidt 12 TegoBetaine F 50 Cocamidopropyl Betaine 3.00 Goldschmidt 13 Polyox WSR-205PEG 14M 0.05 Amerchol 14 Ninol LMP Lauramide MEA 1.00 Stephan 15DL-Panthenol-50% Panthenol 0.15 Roche 16 Phytantriol Phytantriol 0.025Roche 17 Hydrotriticum WAA Wheat Amino Acid 0.22 Croda 18 SodiumBenzoate Sodium Benzoate 0.20 EM Industries 19 Versene 100XL TetrasodiumEDTA 0.20 Dow Chemical 20 BHT Butylated Hydroxytoluene 0.10 EMIndustries 21 Lorena Fragrance 0.50 Creation Aromatiques 22 Glycacil LIodopropynyl butylcarbamate 0.05 Lonza 23 NaOH (25%) Sodium Hydroxide QSMallinckrodt Total 100.00

[0193] Shampoo Process:

[0194] A vessel was charged with ¾ amount of deionized water (component1). Components 2, 3 and 4 were added sequentially thereto, both with tenminute intervals between the additions and with mixing at 500 rpm underconstant conditions. The resulting mixture was then heated to about 63to 67° C. with mixing at 500 rpm. Component 5 was then to the mixture.After all the elubiol had dissolved, salicylic acid (component 6) wasadded thereto with mixing for 15-20 minutes at constant conditions. Theresultant mixture was then heated to 70-75° C. and components 7, 8, 9and 10 were sequentially added under mixing. Component 9 through 13 weresequentially added thereto with mixing under constant conditions. Theresultant primary mixture was then cooled to 50° C.

[0195] Components 15, 16, 20 and 21 were combined in a separate beakerat 25-30° C. to form a premixture. After cooling the primary mixture to50° C., component 14, component 17, the premixture, component 18,component 19 and component 22 were sequentially added thereto withmixing. Sodium hydroxide was added thereto with mixing to adjust the pHto about 5.3-5.7. The mixture was then continuously mixed and cooled toabout 25-30° C. The remaining amount of deionized water was added to thefinal volume and was mixed at 500 rpm until uniform.

Example 2 Preparation of Cleansing Shampoo containing Three CationicAgents

[0196] Shampoos comprised of the following components as set forth inTable 2 were prepared: TABLE 2 Cleansing shampoo with three cationicdeposition enhancing agents. Trade Name CTFA % wt/wt Supplier 1 DI WaterDI Water 72.665 2 Salcare SC 60 Acrylamidopropylltrimoniumchloride 0.08Ciba Specialty Acrylamide Copolymer 3 Jaguar C 17 Guar HydroxypropylTrimonium 0.15 Rhone-Poulenc Chloride 4 Citric Acid Anh Citric Acid0.025 Roche 5 Cutina AGS Glycol Distearate 1.75 Henkel Corporation 6Methyl Paraben Methyl Paraben 0.20 Nipa Hardwicke Inc. 7 Merquat 2001Polyquaternium 47 0.30 Calgon 8 Empicol EAC 70 Ammonium Laureth Sulfate3.6 Albright & Wilson 9 Empicol AL 70 Ammonium Lauryl Sulfate 11.8Albright & Wilson 10 Tego Betaine E Cocamidopropyl Betaine 2.43Goldschmidt 11 Tego Betaine F 50 Cocamidopropyl Betaine 3.00 Goldschmidt12 Elubiol Dicholorohenyl Imidazoldioxolan 0.50 Janssen Pharm. 13Salicylic Acid Salicylic Acid 1.00 Rhone-Poulenc 14 Polyox WSR-205 PEG14M 0.05 Amerchol 15 Ninol LMP Lauramide MEA 1.00 Stepan 16DL-Panthenol-50% Panthenol 0.15 Roche 17 Phytantriol Phytantriol 0.025Roche 18 Hydrotriticum WAA Wheat Amino Acid 0.22 Croda 19 SodiumBenzoate Sodium Benzoate 0.20 EM Industries 20 Versene 100XL TetrasodiumEDTA 0.20 Dow Chemical 21 BHT Butylated Hydroxytoluene 0.10 EMIndustries 22 Lorena Fragrance 0.50 Creation Aromatiques 23 Glycacil LIodopropynyl butylcarbamate 0.05 Lonza 24 NaOH (25%) Sodium Hydroxide QSMallinckrodt 100.00

[0197] Shampoo Process:

[0198] A vessel was charged with ¾ amount of deionized water (component1). Components 2, 3 and 4 were added sequentially, with ten minuteintervals between the additions and with mixing at 500 rpm underconstant conditions. The resulting mixture was then heated to about 70to 75° C. with mixing at 500 rpm. Component 5 and 6 were added and mixedat 500 rpm until dispersed for about 15 to 25 minutes. At 70 to 75° C.,components 9 through 11 were added with mixing.

[0199] After cooling the resultant mixture to about 63 to 67° C.,elubiol, salicylic acid (component 6) and component 14 were addedsequentially thereto with mixing until the latter three components werecompletely dispersed. The resultant primary mixture was then cooled to50° C.

[0200] Components 15, 16, 20 and 21 were combined in a separate beakerat 25-30° C. to form a premixture. After cooling the primary mixture to50° C., components 15 and 18 were added thereto. The premixture followedby components 19, 20 and 23 were then added thereto sequentially withmixing. Sodium hydroxide was then added thereto with mixing to adjustthe pH to about 5.3-5.7. The mixture was continuously mixed and cooledto about 25-30° C. The remaining amount of deionized water was added tothe final volume and was mixed at 500 rpm until uniform.

Example 3 Preparation of Cleansing Shampoo containing Two CationicAgents and One Silicone Quaternary Compound.

[0201] Shampoos comprised of the following components as set forth inTable 3 were prepared: TABLE 3 Cleansing shampoo with two cationicdeposition enhancing agents and a silicone compound. Trade Name CTFA %wt/wt Supplier 1 DI Water DI Water 72.765 2 Salcare SC 60Acrylamidopropylltrimoniumchloride 0.08 Ciba Industries AcrylamideCopolymer 3 Jaguar C 17 Guar Hydroxypropyl Trimonium 0.15 Rhone-PoulencChloride 4 Citric Acid Anh Citric Acid 0.025 5 Cutina AGS GlycolDistearate 1.75 Henkel Corporation 6 Methyl Paraben Methyl Paraben 0.20Nipa Hardwicke Inc 7 Empicol EAC 70 Ammonium Laureth Sulfate 3.6Albright & Wilson 8 Empicol AL 70 Ammonium Lauryl Sulfate 11.8 Albright& Wilson 9 Tego Betaine E Cocamidopropyl Betaine 2.43 Goldschmidt 10Tego Betaine F 50 Cocamidopropyl Betaine 3.00 Goldschmidt 11 ElubiolDicholorohenyl Imidazoldioxolan 0.50 Janssen Pharm. 12 Salicylic AcidSalicylic Acid 1.00 Rhone-Poulenc 13 Polyox WSR-205 PEG 14M 0.05Amerchol 14 Ninol LMP Lauramide MEA 1.00 Stepan 15 DL-Panthenol-50%Panthenol 0.15 Roche 16 Phytantriol Phytantriol 0.025 Roche 17 BiosilBasics SPQ Silicone Quaternium-13 0.20 Biosil 18 Hydrotriticum WAA WheatAmino Acid 0.22 Croda 19 Sodium Benzoate Sodium Benzoate 0.20 EMIndustries 20 Versene 100XL Tetrasodium EDTA 0.20 Dow Chemical 21 BHTButylated Hydroxytoluene 0.10 EM Industries 22 Lorena Fragrance 0.50Creation Aromatiques 23 Glycacil L Iodopropynyl butylcarbamate 0.05Lonza 24 NaOH (25%) Sodium Hydroxide QS Mallinckrodt 100.00

[0202] Shampoo Process:

[0203] A vessel was charged with ¾ amount of deionized water (component1). Components 2, 3 and 4 were added sequentially, with ten minuteintervals between the additions and with mixing at 500 rpm underconstant conditions. The resulting mixture was then heated to about 70to 75° C. with mixing at 500 rpm. Component 5 and 6 were added and mixedat 500 rpm until dispersed for about 15 to 25 minutes. At 70 to 75° C.,components 7 through 11 were added with mixing.

[0204] After cooling the resultant mixture to about 63 to 67° C.,elubiol, salicylic acid (component 6) and component 14 were addedsequentially thereto with mixing until the latter three components werecompletely dispersed. The resultant primary mixture was then cooled to50° C.

[0205] Components 15, 16, 21 and 22 were combined in a separate beakerat 25-30° C. to form a premixture. After cooling the primary mixture to50° C., components 14, 17 and 18 were added. The premixture followed bycomponents 19, 20 and 23 were added thereto sequentially with mixing.Sodium hydroxide was added thereto with mixing to adjust the pH to about5.3-5.7. The mixture was continuously mixed and cooled to about 25-30°C. The remaining amount of deionized water was added to the final volumeand was mixed at 500 rpm until uniform.

Example 4 Preparation of Cleansing Shampoo containing Three CationicAdditives and Two Silicone Quaternary Compounds

[0206] Shampoos comprised of the following components as set forth inTable 4 were prepared: TABLE 4 Cleansing shampoo with three cationicdeposition enhancing agents and two silicon compounds. Trade Name CTFA %wt/wt Supplier 1 DI Water DI Water 72.32 2 Salcare SC 60Acrylamidopropylltrimoniumchloride 0.08 Ciba Specialty AcrylamideCopolymer 3 Jaguar C 17 Guar Hydroxypropyl Trimonium Chloride 0.15Rhone-Poulenc 4 Citric Acid Anh Citric Acid 0.025 5 Cutina AGS GlycolDistearate 1.75 Henkel Corporation 6 Methyl Paraben Methyl Paraben 0.20Nipa Hardwicke Inc. 7 Merquat 2001 Polyquaternium 47 0.30 Calgon 8Empicol EAC 70 Ammonium Laureth Sulfate 3.60 Albright & Wilson 9 EmpicolAL 70 Ammonium Lauryl Sulfate 11.8 Albright & Wilson 10 Tego Betaine ECocamidopropyl Betaine 2.43 Goldschmidt 11 Tego Betaine F 50Cocamidopropyl Betaine 3.00 Goldschmidt 12 Elubiol DicholorohenylImidazoldioxolan 0.50 Janssen Pharm. 13 Salicylic Acid Salicylic Acid1.00 Rhone-Poulenc 14 Polyox WSR-205 PEG 14M 0.05 Amerchol 15 Ninol LMPLauramide MEA 1.00 Stepan 16 Biosil Basics SPQ Silicone Quaternium-130.20 Biosil Technologies Inc. 17 Biosil Basics Cetylsil CetylTriethylmonium-Dimethicone 0.15 Biosil Copolyol Phthalate TechnologiesInc. 18 DL-Panthenol-50% Panthenol 0.15 Roche 19 Phytantriol Phytantriol0.025 Roche 20 Hydrotriticum WAA Wheat Amino Acid 0.22 Croda 21 SodiumBenzoate Sodium Benzoate 0.20 EM Industries 22 Versene 100XL TetrasodiumEDTA 0.20 Dow Chemical 23 BHT Butylated Hydroxytoluene 0.10 EMIndustries 24 Lorena Fragrance 0.50 Creation Aromatiques 25 Glycacil LIodopropynyl butylcarbamate 0.05 Lonza 26 NaOH (25%) Sodium Hydroxide QSMallinckrodt 100.00

[0207] Shampoo Process:

[0208] A vessel was charged with ¾ amount of deionized water (component1). Components 2, 3 and 4 were added sequentially, with ten minuteintervals between the additions and with mixing at 500 rpm underconstant conditions. The resulting mixture was then heated to about 70to 75° C. with mixing at 500 rpm. Component 5 and 6 were added theretoand mixed at 500 rpm until dispersed, i.e., for about 15 to 25 minutes.At 70 to 75° C., components 7 through 11 were added thereto with mixing.

[0209] After cooling the resultant mixture to about 63 to 67° C.,elubiol, salicylic acid (component 13) and component 14 were addedsequentially thereto with mixing until the latter three components werecompletely dispersed therein. The resultant primary mixture was thencooled to 50° C.

[0210] Components 18, 19,23 and 24 were combined in a separate beaker at25-30° C. to form a premixture. After cooling the primary mixture to 50°C., components 15, 16, 17 and 20 were added thereto. The premixturefollowed by components 21, 22 and 25 added thereto sequentially withmixing. Sodium hydroxide was then added thereto with mixing to adjustthe pH to about 5.3-5. The mixture was continuously mixed and cooled toabout 25-30° C. The remaining amount of deionized water was added to thefinal volume and was mixed at 500 rpm until uniform.

Example 5 Preparation of Cleansing Shampoo containing Three CationicAdditives and One Silicone Quaternary Compounds

[0211] Shampoos comprised of the following components as set forth inTable 5 were prepared: TABLE 5 Cleansing shampoo with three cationicdeposition enhancing agents and one silicon compound. Trade Name CTFA %wt/wt Supplier 1 DI Water DI Water 72.82 2 Salcare SC 60Acrylamidopropylltrimoniumchloride 0.08 Ciba Specialities AcrylamideCopolymer 3 Jaguar C17 Guar Hydroxypropyl Trimonium 0.15 Rhone-PoulencChloride 4 Citric Acid Anh Citric Acid 0.025 Roche 5 Cutina AGS GlycolDistearate 1.75 Henkel Corporation 6 Methyl Paraben Methyl Paraben 0.20Nipa Hardwicke Inc. 7 Empicol EAC 70 Ammonium Laureth Sulfate 3.6Albright & Wilson 8 Empicol AL 70 Ammonium Lauryl Sulfate 11.8 Albright& Wilson 9 Tego Betaine E Cocamidopropyl Betaine 2.43 Goldschmidt 10Tego Betaine F Cocamidopropyl Betaine 3.00 Goldschmidt 50 11 ElubiolDichlorophenyl 0.500 Janssen Pharm. Imidazoldioxolan 12 Salicylic AcidSalicylic Acid 1.000 Rhone-Poulenc 13 Polyox WSR-205 PEG 14M 0.05Amerchol 14 Ninol LMP Lauramide MEA 1.00 Stepan 15 Biosil Basics CetylTriethylmonium- 0.15 Biosil Technologies Inc. Cetylsil DimethiconeCopolyol Phthalate 16 Hydrotriticum Wheat Amino Acid 0.220 Croda WAA 17DL-Panthenol- Panthenol 0.15 Roche 50% 18 Phytantriol Phytantriol 0.025Roche 19 Sodium Benzoate Sodium Benzoate 0.20 EM Industries 20 Versene100XL Tetrasodium EDTA 0.20 Dow Chemical 21 BHT Butylated Hydroxytoluene0.10 EM Industries 22 Lorena Fragrance 0.50 Creation Aromatiques 23Glycacil L Iodopropynyl butylcarbamate 0.05 Lonza 24 Citric Acid CitricAcid (50%) QS Mallinckrodt Total 100.00

[0212] Shampoo Process:

[0213] A vessel was charged with ¾ amount of deionized water (component1). Components 2, 3 and 4 were added sequentially, with ten minuteintervals between the additions and with mixing at 500 rpm underconstant conditions. The resulting mixture was then heated to 70 to 75°C. with mixing at 500 rpm. Components 5 and 6 were then to the mixturewith mixing for about 15 to 25 minutes. The resultant mixture wasmaintained at 70-75° C., and components 7 through 10 were sequentiallyadded thereto with mixing.

[0214] After the resultant mixture was cooled to about 63-67° C.,elubiol (component 11) was added thereto with mixing under constantconditions. Salicylic acid was then added thereto followed by component13 under constant mixing to form a primary mixture.

[0215] Components 15, 16, 21 and 22 were combined in a separate beakerat 25-30° C. to form a premixture. After cooling the primary mixture to50° C., components 14, 17, and 18 were sequentially added thereto withmixing. The premixture was then added thereto. Sodium hydroxide was thenadded thereto with mixing to adjust the pH to about 5.3-5.7. The mixturewas continuously mixed and cooled to about 25-30° C. The remainingamount of deionized water was added to the final volume and was mixed at500 rpm until uniform.

Example 6 Preparation of Cleansing Shampoo

[0216] Shampoos comprised of the following components as set forth inTable 6 were prepared: TABLE 6 Cleansing shampoo. Trade Name CTFA %wt/wt Supplier 1 DI Water DI Water 73.225 2 Cutina AGS Glycol Distearate1.75 Henkel Corporation 3 Methyl Paraben Methyl Paraben 0.20 NipaHardwicke Inc. 4 Empicol EAC 70 Ammonium Laureth Sulfate 3.60 Albright &Wilson 5 Empicol AL 70 Ammonium Lauryl Sulfate 11.80 Albright & Wilson 6Tego Betaine E Cocamidopropyl Betaine 2.43 Goldschmidt 7 Tego Betaine F50 Cocamidopropyl Betaine 3.00 Goldschmidt 8 Elubiol DichlorophenylImidazoldioxolan 0.50 Janssen Pharm. 9 Salicylic Acid Salicylic Acid1.00 Rhone-Poulenc 10 Polyox WSR-205 PEG 14M 0.05 Amerchol 11 Ninol LMPLauramide MEA 1.00 Stepan 12 Hydrotriticum Wheat Amino Acid 0.22 CrodaWAA 13 DL-Panthenol- Panthenol 0.15 Roche 50% 14 Phytantriol Phytantriol0.025 Roche 15 Sodium Benzoate Sodium Benzoate 0.20 EM Industries 16Versene 100XL Tetrasodium EDTA 0.20 Dow Chemical 17 BHT ButylatedHydroxytoluene 0.10 EM Industries 18 Lorena Fragrance 0.50 CreationAromatigues 19 Glycacil L Iodopropynyl butylcarbamate 0.05 Lonza 20 NaOHNaOH (25%) QS Mallinckrodt Total 100.00

[0217] Shampoo Process:

[0218] A vessel was charged with ¾ amount of deionized water(component 1) and heated to about 70 to 75° C. Components 2 and 3 wereadded thereto with mixing at 500 rpm under constant conditions for 15 to20 minutes. Component 4 through 7 were added sequentially thereto withmixing under constant conditions. After the resultant mixture was thencooled to 63-67° C., elubiol (component 11) was added thereto withmixing under constant conditions. Salicylic acid was then added theretofollowed by component 10 under constant mixing to form a primarymixture. Components 13, 14, 17 and 18 were combined in a separate beakerat 25-30° C. to form a premixture. After cooling the primary mixture to50° C., the premixture was added thereto, then components 15, 16 and 19were sequentially added thereto with mixing. Sodium hydroxide was thenadded thereto with mixing to adjust the pH to about 5.3-5.7. The mixturewas then continuously mixed and cooled to about 25-30° C. The remainingamount of deionized water was added to the final volume and was mixed at500 rpm until uniform.

Example 7 Preparation of Cleansing Shampoo Containing One Water SolubleSilicone Compound

[0219] Shampoos comprised of the following components as set forth inTable 7 were prepared: TABLE 7 Cleansing shampoo with one water solublesilicone deposition enhancing agents. Trade Name CTFA % wt/wt Supplier 1DI Water DI Water 73.00 2 Citric Acid Anh Citric Acid 0.025 Roche 3Cutina AGS Glycol Distearate 1.75 Henkel 4 Methyl Paraben Methyl Paraben0.20 Mallinckrodt 5 Empicol EAC 70 Ammonium Laureth Sulfate 3.6 Albright& Wilson 6 Empicol AL 70 Ammonium Lauryl Sulfate 11.8 Albright & Wilson7 Tego Betaine E Cocamidopropyl Betaine 2.43 Goldschmidt 8 Tego BetaineF 50 Cocamidopropyl Betaine 3.00 Goldschmidt 9 Elubiol DichlorophenylImidazoldioxolan 0.50 Janssen Pharm. 10 Salicylic Acid Salicylic Acid1.00 Rhone-Poulenc 11 Polyox WSR-205 PEG 14M 0.05 Amerchol 12 Ninol LMPLauramide MEA 1.00 Stephan 13 DL-Panthenol-50% Panthenol 0.15 Roche 14Phytantriol Phytantriol 0.025 Roche 15 Biosil Basic SPQ SiliconeQuaternium 13 0.20 Biosil 16 Hydrotriticum WAA Wheat Amino Acid 0.22Croda 17 Sodium Benzoate Sodium Benzoate 0.20 EM Industries 18 Versene100XL Tetrasodium EDTA 0.20 Dow Chemical 19 BHT Butylated Hydroxytoluene0.10 EM Industries 20 Lorena Fragrance 0.50 Creation Aromatiques 21Glycacil L Iodopropynyl butylcarbamate 0.05 Lonza 22 NaOH (25%) SodiumHydroxide QS Mallinckrodt Total 100.00

[0220] Shampoo Process:

[0221] A vessel was charged with ¾ amount of deionized water (component1). Components 2 was then added thereto. The resultant mixture was thenheated to 70-75° C., and components 3 & 4 were sequentially addedthereto with mixing at 500 rpm under constant conditions. Component 5through 8 were then sequentially added thereto with mixing underconstant conditions. The resulting mixture was cooled to about 63 to 67°C. with mixing at 500 rpm. Component 9 was then added to the mixture.After all the elubiol had dissolved therein, salicylic acid (component10) was added thereto with mixing for 15-20 minutes at constantconditions; component 11 then was added thereto. The resultant primarymixture was then cooled to 50° C.

[0222] Components 13, 14, 19 and 20 were combined in a separate beakerat 25-30° C. to form a premixture. After cooling the primary mixture to50° C., component 12, component 15, component 16, the premixture,component 17, component 18 and component 21 were sequentially addedthereto with mixing. Sodium hydroxide was added thereto with mixing toadjust the pH to about 5.3-5.7. The mixture was continuously mixed andcooled to about 25-30° C. The remaining amount of deionized water wasadded to the final volume and mixed at 500 rpm until uniform.

Example 8 Preparation of Cleansing Shampoo Containing Two Water SolubleSilicone compounds

[0223] Shampoos comprised of the following components as set forth inTable 8 were prepared: TABLE 8 Cleansing shampoo with two water solublesilicone deposition enhancing agents. Trade Name CTFA % wt/wt Supplier 1DI Water DI Water 73.00 2 Citric Acid Anh Citric Acid 0.025 Roche 3Cutina AGS Glycol Distearate 1.75 Henkel 4 Methyl Paraben Methyl Paraben0.20 5 Empicol EAC 70 Ammonium Laureth Sulfate 3.6 Albright & Wilson 6Empicol AL 70 Ammonium Lauryl Sulfate 11.8 Albright & Wilson 7 TegoBetaine E Cocamidopropyl Betaine 2.43 Goldschmidt 8 Tego Betaine F 50Cocamidopropyl Betaine 3.00 Goldschmidt 9 Elubiol DichlorophenylImidazoldioxolan 0.50 Janssen Pharm. 10 Salicylic Acid Salicylic Acid1.00 Rhone-Poulenc 11 Polyox WSR-205 PEG 14M 0.05 Amerchol 12 Ninol LMPLauramide MEA 1.00 Stephan 13 DL-Panthenol-50% Panthenol 0.15 Roche 14Phytantriol Phytantriol 0.025 Roche 15 Biosil Basic SPQ SiliconeQuaternium 13 0.20 Biosil 16 Biosil Basic Cetylsil CetylTriethylammonium Dimethicone 0.15 Biosil Copolyol Phthalate 17Hydrotriticum WAA Wheat Amino Acid 0.22 Croda 18 Sodium Benzoate SodiumBenzoate 0.20 EM Industries 19 Versene 100XL Tetrasodium EDTA 0.20 DowChemical 20 BHT Butylated Hydroxytoluene 0.10 EM Industries 21 LorenaFragrance 0.50 Creation Aromatiques 22 Glycacil L Iodopropynylbutylcarbamate 0.05 Lonza 23 NaOH (25%) Sodium Hydroxide QS MallinckrodtTotal 100.00

[0224] Shampoo Process:

[0225] A vessel was charged with ¾ amount of deionized water (component1). Components 2 was then added thereto. The resultant mixture was thenheated to 70-75° C. and components 3 and 4 were sequentially addedthereto with mixing at 500 rpm under constant conditions. Component 5through 8 were sequentially added thereto with mixing under constantconditions. After cooling the resulting mixture to about 63 to 67° C.with mixing at 500 rpm, component 9 was then added to the mixture. Afterall the elubiol had dissolved therein, salicylic acid (component 10) wasadded thereto with mixing for 15-20 minutes at constant conditions;component 11 was then added thereto. The resultant primary mixture wasthen cooled to 50° C.

[0226] Components 13, 14, 20 and 21 were combined in a separate beakerat 25-30° C. to form a premixture. After cooling the primary mixture to50° C., component 12, component 15, component 16, component 17 thepremixture, component 18, component 19 and component 22 weresequentially added thereto with mixing. Sodium hydroxide was then addedthereto with mixing to adjust the pH to about 5.3-5.7. The mixture wascontinuously mixed and cooled to about 25-30° C. The remaining amount ofdeionized water was added to the final volume and was mixed at 500 rpmuntil uniform.

Example 9 Multiple Attribute Assessment Study

[0227] A large-scale consumer study was conducted to assess a variety ofattributes such as cleansing ability; hair combing attributes (e.g. wetcombing and dry combing); hair softness; and lather attributes (e.g. theamount of lather and the creaminess of the lather). The fourformulations tested in this study included: 1) the formulation preparedin accordance with Example 3; 2) “Pantene Pro-V” regular shampoo fornormal hair commercially available from Procter & Gamble; 3) “Johnson'spH 5.5” regular shampoo for normal hair commercially available fromJohnson & Johnson Consumer Companies, Inc.; and 4) “Johnson's pH 5.5”regular shampoo modified with a different fragrance.

[0228] For each of the four above-mentioned test products, 250 femalesubjects between the age of 16-65 who use regular shampoos for normalhair were selected to participate in a blinded, monadic in-home usestudy. After using the test product for 2 weeks, each subject completeda questionnaire which asked them to rate the overall performance of thetest product as well as and various attributes associated therewith.

[0229] The following table is a summary of the results from study: TABLE9 % of subjects satisfied with the performance of the product in eachattribute listed. Example #3 pH 5.5 (base w/2 cationic with modifiedagents & 1 silicone pH 5.5 fragrance agent) Pantene Attributes (a) (b)(c) (e) Cleaning 88% 86% (4) 91% (3) 88% Wet combing 71% (2) 66% (2) 83%(1) (3) 77% (4) Dry combing 72% (2) 78% (2) 86% (1) 83% Hair Softness78% (2) 78% (2) 90% (1) 86% Amount of 41% 37% (2) 47% (1) (3) 38% (4)lather Creaminess 14% (2) 11% (2) 27% (1) (3) 21% (4) of lather (Verycreamy)

[0230] This Example showed that the formulation of Example 3 rankedsuperior with respect to the subject's satisfaction in all theattributes listed above. More specifically, the formulation of Example 3performed significantly better relative to the performance of the pH 5.5product with either the original and modified fragrance with respect tothe following attributes: wet combing, dry combing, hair softness,cleansing, amount of lather and creaminess of the lather. Theformulation of Example 3 also performed significantly superior relativeto the performance of Pantene with respect to wet combing, amount oflather and creaminess of the lather. This Example showed that thesubjects perceived that the formulation of Example 3 performed the bestoverall with respect to the attributes tested.

Example 10 Hair Softness Assessment

[0231] 80 Caucasian females between the ages of 18 and 65 years old wereselected to participate in a blind hair softness assessment studyconducted by professional hair stylists. Prior to participating in thestudy, each subject did not wash their hair for a period of 24 hoursprior to the study entry. All of the subjects as well as the stylistcompleted two different questionnaires relating to the hair quality andhair softness of each panelist before the study commenced.

[0232] The following three methods were used for purposes of assessinghair softness: 1) pat and compress hair with hands; 2) run fingersthrough the hair; and 3) feel the hair fibers/strands with fingers.

[0233] After 3 cc of the formulation of Example 3 was applied via asyringe onto the hair on each respective subject's head, the stylistthen shampooed the hair of each respective subject. After this procedurewas repeated twice per subject, the hair of each subject was then blownuntil the hair was completely dried. No other styling aides were used onhair or scalp of any of the subjects. After the drying procedure, boththe respective subject as well as the stylist conducted an independentevaluation of the respective subject's hair softness, using the Softnessscale as set forth in Table 10 below. The results of the evaluations areset forth in Table 11 below. TABLE 10 Softness Scale Number ScoreSoftness Assessment 0 Not At all Soft 1 Just Barely Soft 2 Between JustBarely and Slightly Soft 3 Slightly Soft 4 Slightly to Moderately Soft 5Moderately Soft 6 Moderately to Considerably Soft 7 Considerable Soft 8Considerably to Very Soft 9 Very Soft 10 Extremely Soft

[0234] TABLE 11 Softness assessments determine by the subject andstylist. The numbers represent the mean score from 80 subjects. Pre-washsoftness Evaluator score Post-Wash Score p-value Stylist 2.74 7.440.0001 Subject 3.50 7.58 0.0001

[0235] It is evident from the data above that the formulation of Example3 significantly increased the softness of the hair as determinedindependently by the stylist and the subjects.

[0236] Each respective subject as well as the stylist also conducted anindependent, post-drying evaluation of the degree of softness of eachrespective subject's hair, using the Hair Softness Quantification Scaleas set forth in Table 12 below. The results of the evaluations are setforth in Table 13below. TABLE 12 Hair Softness Qualification ScaleNumber Scale Distinction −1 Less Soft 0 The Same 1 Somewhat Softer 2Twice as Soft 3 Three times as soft 4 More than Three times as soft

[0237] TABLE 13 Qualification of the hair softness. The numbers belowrepresent mean score values from 80 subjects. Evaluator Mean TimesSofter Score p-value Stylist 2.44 0.0001 Subject 2.33 0.0001

[0238] From the data above, it is evident that the formulation ofExample 3 was approximately two to three times more soft as a result ofshampooing with this cleansing base.

Example 11 Secondary Ion Mass Spectrometry (SIMS) to Assess SiDeposition

[0239] A formulation was prepared in accordance with the procedure setforth in Example 3, except that: a) the Biosil SPQ silicone agent wasused instead at a concentration of 1 weight percent as opposed to 0.2weight percent; b) the Salcare cationic agent was used instead at aconcentration of 0.05 weight percent as opposed to 0.08 weight percent;and c) the Jaguar cationic agent was used instead at a concentration of0.1 weight percent as opposed to 0.15 weight percent.

[0240] One hair tress was independently washed five times, followed bycomplete drying of the tress in between washings, with Pantene Pro-V2-in-1 shampoo for normal hair that is commercially available from TheProcter and Gamble Company, and another hair tress was similarly washedwith the formulation of Example 3 as modified in Example 11 and dried.

[0241] Scanning SIMS (secondary ion mass spectrometry) was then used tocharacterize the distribution of silicone ions from thesilicone-containing polymers that were deposited on the hair. Details ofSIMS may be found in, for example, Sibilia, John, “A Guide to MaterialCharacterization and Chemical Analysis,” Ch. 8, 185-192(1988)(hereinafter “Sibilia”), which is incorporated by referenceherein. After placing one fiber of each tress in a Physical ElectronicsSIMS spectrometer, a primary ion beam was then scanned across the hairsurface in order to ionize the Si molecules from the hair surface. Thespectrometer then generated images revealing the distribution of Si ionson the surface of the hair.

[0242] This procedure was repeated with several hair fibers from eachtress, and representative mass spectrometer images were taken of eachset of hair fibers.

[0243] It is evident from FIG. 1, which illustrates the distribution ofSi ions on the hair surface that was washed with the Pantene Pro-Vshampoo, that the Si ions were distributed over the surface hair fiber;however, the ions were primarily concentrated only under the scale ridgeof the hair fiber. By contrast, it is evident from FIG. 2, whichillustrates the distribution of Si ions on the hair surface that waswashed with the modified Example 3 formulation, that the distribution ofthe Si ions is comparatively more homogenous than the distribution shownby the hair fibers washed with the Pantene Pro-V shampoo.

[0244] This Example showed that the cleansing composition of the presentinvention yielded a more homogeneous distribution of the Siliconepolymers, which thereby significantly contributed to the improvedsoftness and body of the treated hair fibers.

Example 12 X-Ray Photoelectron Spectrometer (XPS) to Assess PolymerThickness

[0245] After each tress of Example 11 was placed into a PhysicalElectronics x-ray photoelectron spectrometer, a beam of X-rays werescanned onto the surface of the hair fibers. Details of XPS may be foundin, for example, Sibilia at 197-199, which is incorporated by referenceherein.

[0246] From the percentage of Carbon and Oxygen atoms on the hair fiberand the atomic ratios of Si:C and Si:O as determined by XPS, thethickness of the silicone polymer layer on the hair surface wasestimated as shown in Table 14 below: TABLE 14 Thickness of Siliconemolecules on the hair as determined by XPS. Thickness of Si moleculesFormulation (Angstroms) Number of monolayers Pantene Pro-V 40-50 7-8Modified Example 3 3 1

[0247] It is evident from the results of Table 14 that the Panteneshampoo left substantially higher levels of silicon molecular residue onthe hair surface in comparison to the amount of such residue left by themodified Example 3 formulation. We believe that the higher levels ofsilicon deposition along the hair surface may contribute to theperception of high conditioning build-up on the hair, reduction in body,and limpness. By contrast, since the hair treated with the modifiedExample 3 formulation left only one or two layers of silicon molecularresidue on the surface of the hair fibers, we believe that hair treatedwith this formulation will likely possess attributes, such as enhancedwet and dry comb, improved rinsing performance and enhanced softness,that are superior relative to such properties possessed by hair treatedwith the Pantene shampoo.

[0248] Since the performance of a hair care product largely depends uponon how the product interacts with the outermost layer of the hair fiber,this example indicated that the modified Example 3 shampoo will have asuperior performance relative to that of the Pantene shampoo based upona chemical and elemental analysis of the respective shampoo's residueleft at the interface between the hair surface and the air.

Example 13 Instron Ring Compression Study to Assess Hair Softness andBody

[0249] The ring compression technique, which measures the energyrequired to pull hair tresses through various sized rings both beforeand after the tresses are shampooed, is a well known technique asdescribed in Wergmann & Kamuth, Principles of Polymer Science andTechnology in Cosmetics and Personal Care, Chapter 12 “EvaluationMethods for Conditioned Hair” 554-556 (1999), which is incorporatedherein by reference, for assessing hair softness and body. See, e.g.,Garcia et al, “Measurement of Bulk Compressibility and Bulk Resiliencyof a Hair Mass,” 10^(th) IFTSCC Congress, Sidney, Australia (1978),which is incorporated by reference herein. The apparatus used in thistechnique consisted of an Instron tensile tester, model 1122, which isconnected to ring devices of varying diameters.

[0250] After 15 brown European hair tresses were permed with a tightperm, each tress was pulled through a metal ring having a 1.5″ innerdiameter twice. The energy required to pull the tress through the ringwas then recorded via the Instron tester. The tresses were then manuallyloosened and pulled through a second metal ring having a 1.0″ innerdiameter twice. The energy required to pull the tress through thissecond ring was then recorded via the Instron tester.

[0251] The “Dry Pull Energy” required to pull a tress through a givenring may be expressed in terms of the difference between the energyexerted to pull a tress through the same ring twice. This value is ameasure of the degree of body or rebound of the hair tress aftercompression. Higher values of Dry Pull Energy indicate greater hairbody.

[0252] The difference between the Dry Pull Energies required to pulleach tress through the 1.0″ and the 1.5″ diameter rings, respectively,is an indication of the softness of the hair tress. The greater thedifference between the difference in the Dry Pull Energies indicatesthat the respective hair tress is relatively more compressible orsofter. The difference in the Dry Pull Energies resulting from the tressbeing pulled through a 1.0″ inch ring and then through a 1.5″ inchdiameter ring are shown in Table 15 and 16 below for the dry permedhair.

[0253] The tresses were then shampooed once with one of the followingproducts: 1) the formulation of Example 3; 2) “Pantene Pro-V” shampoofor normal hair; and 3) “Shiseido Super Mild” shampoo commerciallyavailable from Shiseido Fine Toiletries Co., LTD. A minimum of 3 tresseswas used for each product. After the tresses were shampooed and blowncompletely dry, the tresses were manually loosened to separate theindividual hair fibers. The tresses were then pulled through the ringsin accordance with the procedures as described above.

[0254] The difference in the Dry Pull Energies resulting from the tressbeing pulled through the same size ring twice, i.e. a 1.0″ diameter ringand independently a 1.5″ diameter ring, both before the hair isshampooed as well as after the hair is both shampooed and dried areshown in the Table 17 below. TABLE 15 Dry Pull Energy (mJ) Dry PullEnergy Dry Pull Difference Between Dry Before Energy After Pull EnergyBefore and Test Product Shampooing Shampooing After treatments Example 316.0 10.0 6.0 Pantene Pro V 20.3 16.8 3.5 Shiseido Super 7.99 7.90 0.09Mild

[0255] TABLE 16 Statistical significance of represented by p-valuesdetermined by the Student's t-test*. Formulations p-value Example 3 vs.Pantene >0.000 Example 3 vs. Shiseido 0.026

[0256] It is evident from the data above that the formulation of Example3 showed the greatest difference in Dry Pull Energies, which indicatesthat this formulation is superior with respect to the other two testedcommercial formulations with respect to delivering softness to the hairfibers. TABLE 17 Dry Pull Energy (mJ) Difference Difference Dry Pullbetween Dry Dry Pull between Dry Energy Dry Pull Pull Energy Dry PullPull Before Energy After Energies Before Energy After Energiesshampooing Shampooing before and shampooing Shampooing Before and PulledPulled after Pulled Pulled After Test through 1.0″ through 1.0″shampooing through 1.5″ through 1.5″ Shampooing Product Ring Ring (1.0″ring) Ring Ring (1.5″ ring) Example 3 2.76 1.31 1.45 2.20 1.07 1.13Pantene Pro V 2.39 1.56 0.83 2.19 1.43 0.76 Shiseido 1.26 1.05 0.21 1.340.93 0.41 Super Mild

[0257] It is evident from the data in Table 17 above that theformulation of Example 3 showed the greatest difference in Dry PullEnergy before and after shampooing regardless of the ring size employed.This indicates that the formulation of Example 3 exhibited the greatestamount of body and/or rebound relative to that possessed by the othertwo commercial products.

Example 14 Dynamic Vapor Sorption Studies to Determine Moisture Uptake

[0258] Dynamic Vapor Sorption (DVS), Surface Measurement Systems, Ltd.,was used to determine the water absorption and moisture desorption onhair fibers after application of a composition thereto.

[0259] Four hair tresses were individually shampooed twice with 3 g ofone of the formulations prepared in accordance with one of the followingexamples as shown in Table 18 below: 1) modified Example 3; 2) Example6; 3) modified Example 7; and 4) modified Example 6. After blow dryingthe hair tresses for 2 minutes, the tresses were then cut into segments5-7 mm in length and weighed using a DVS Caln microbalance. The weightsof the hair samples ranged between approximately 30 mg to 40 mg/sample.The hair samples were then placed into the DVS humidity chamber andequilibrated at 0% relative humidity at 25° C. overnight. The relativehumidity in the chamber was then increased to 10% RH until equilibrationoccurred. The relative humidity was then increased to 95% RH inapproximately 10% RH intervals. The weight of the hair samples was thenmeasured at each interval after each equilibration using the Cainmicrobalance. The relative humidity was then reduced back to 10% RH in−10% RH intervals. The weight of the hair fibers at each 10% RH intervalis an indication of the water moisture absorbed and of the moistureretained by the hair samples. The water retaining capacity is thedifference between the measured weight of water retained by the hairfibers at a given relative humidity during the ascent of the relativehumidity versus measured weight of water retained by the hair fibers ata given relative humidity during the descent of the relative humidity.Higher values of water retaining capacity indicate the presence ofsurface water on the hair fiber, which tends to create limpness of thehair or increase interfiber adhesion. Lower values water retainingcapacity indicated the reduction of water by the hair fiber, which tendto increase the body of the hair. A summary of the water retainingcapacities is shown in Table 19 below. TABLE 18 Summary of formulationstested and modifications. Number of Number of Modifications inFormulations Cationic Silicones Formulation Modified Example 3 2 1Jaguar is 0.10 wt % instead of 0.15 wt % Example 6 0 0 No modificationsModified Example 7 0 1 No PEG 14M Modified Example 6 0 0 No PEG 14M

[0260] TABLE 19 Water Retaining Capacities Moderate Relative HighRelative Humidity (calculated at Humidity (calculated at Test Products50% RH) 80% RH Untreated 2.34 1.80 Modified example 3 2.14 1.65 Example6 2.53 1.88 Modified Example 7 2.34 1.82 Modified example 6 2.47 1.99

[0261] It is evident from the data above that the formulation of Example3 as modified above in Table 18 possessed superior body properties atboth moderate and high relative humidity conditions. By contrast, theformulations that did not contain a cationic agent and/or a siliconeagent did not perform relatively as well. This Example showed thatformulations exhibiting superior body preferably contain both at leasttwo cationic agents as well as one silicone agent.

Example 15 Determination of Skin Permeation

[0262] Experiments were conducted to determine the deposition of activesinto the skin from various shampoo compositions. To determinepenetration of actives, in vitro skin permeation studies were conductedusing non-occluded Franz diffusion chambers.

[0263] Human cadaver skin, microtomed to 400 μm, were mounted on Franzdiffusion cells containing a receptor medium composed of a citric acidphosphate buffer or a phosphate buffered solution (depending on theactive being monitored). The receptor capacity was 5 ml and the cellsurface was 0.636 cm². The receptor compartment was maintained at 37° C.during the experiment.

[0264] In a tube, 50 μl of each formulation as shown in Tables 1 and 2through 6 were diluted with 50 μl of 37° C. water. This solution wasthen rubbed onto the epidermal surface of the mounted skin for 30seconds and allowed to sit thereon for 5 minutes. The solution was thenrinsed from the surface three times with 37° C. water, and then swabbedtwice with dry cotton swabs. At 24 hours after the topical applicationof the formulation, the surface of the skin was rinsed three times withmethanol or distilled water soaked cotton swabs (depending on the activeto be monitored), and then swabbed three times with three dry cottonswabs. After removing the skin from the diffusion cell, the epidermisand dermis were separated, chopped and placed into separate vialscontaining an extraction solution and sonicated in a bath sonicator for30 minutes. After sonication of the epidermis, dermis and swabs,respectively, each sonicated sample was assayed using a Walters highpressure liquid chromatography (“HPLC”). Penetration of the active intothe skin was calculated based upon a percentage of the applied dose andthe amount of active delivered into the epidermis or dermis per surfacearea. For these studies, the penetration of a lipophilic agent, elubiolwas investigated. Also the penetration of a hydrophilic agent, salicylicacid was investigated.

[0265] As shown in Table 20 below, the formulations investigated werethe formulations prepared in accordance with the procedures set forth inExample 1, and Examples 3 through 8. Table 21 shows the amount ofelubiol penetrated into the skin (epidermis and dermis) after topicalapplication of the formulations set forth in Table 20 in accordance withthe procedure set forth above. TABLE 20 Summary of Depositing Agents ineach compositions Number of Number Of Example # Depositing Agents(Additives) Cationic Silicones 1 Jaguar, Salcare 2 0 3 Jaguar, Salcare,Biosil SPQ 2 1 4 Jaguar, Salcare, Merquat, Biosil 3 2 SPQ, Biosil Cetyl6 None 0 0 7 Biosil Basic SPQ 0 1 8 Biosil SPQ, Biosil Cetyl 0 2

[0266] TABLE 21 Levels of elubiol in the skin (epidermis and dermis)after topical application of various shampoo formulations. EpidermisDermis Total Skin Delivery Formulations Amt/Surface PercentageAmt/Surface Percentage Number Area of Applied Amt/Surface Percentage ofArea of Applied tested (μg/cm²) Dose % Area (μg/cm²) Applied Dose %(μg/cm²) Dose % #1 1.849 ± 1.316 0.510 ± 0.363 0.139 ± 0.058 0.038 ±0.016 1.988 0.549 #3 3.471 ± 2.009 1.039 ± 0.601 0.173 ± 0.051 0.052 ±0.015 3.644 1.091 #4 8.70 ± 3.35 2.433 ± 0.936 0.121 ± 0.021 0.034 ±0.006 8.822 2.466 #6 0.412 ± 0.051 0.111 ± 0.014 0.089 ± 0.023 0.024 ±0.006 0.502 0.135 #7 0.50 ± 0.14 0.127 ± 0.036 0.398 ± 0.067 0.101 ±0.017 0.899 0.227 #8 0.25 ± 0.02 0.064 ± 0.06  0.034 ± 0.006 0.009 ±0.002 0.279 0.072

[0267] TABLE 22 Statistical significance of elubiol permeation asrepresented by p-values determined by the Student's t-test*.Formulations Epidermis Dermis 4 Vs 6 One Tail = 0.001 One Tail = 0 TwoTail = 0.003 Two Tail = 0 4 Vs 3 One Tail = 0.011 One Tail = 0 Two Tail= 0.022 Two Tail = 0 4 Vs 1 One Tail = 0.002 One Tail = 0 Two Tail =0.004 Two Tail = 0

[0268] The results of Table 21 are summarized below in Table 23. TABLE23 Ranking (from best to worst) of the formulations with respect toelubiol delivery into the skin (epidermis and dermis). Ranked Number ofCationic Number Of Total % of Elubiol Example Agents in SiliconsDelivered into the Number Composition in Composition Skin 4 3 2 2.466 32 1 1.091 1 2 0 0.549 7 0 1 0.227 6 0 0 0.135 8 0 2 0.072

[0269] This Example showed that a formulation (Formulation 4) containing3 cationic agents and 2 silicones delivered 2.466% of the applied doseof elubiol into the skin. However, when a formulation (Formulation 3)containing 2 cationic agents and 1 silicone were incorporated with thecleansing shampoo base, the percentage of elubiol delivered decreased to1.091%, over a 2.2 fold decrease in delivery. When no cationic agentswere incorporated into the cleansing base (Formulation 6), the elubiolpermeation surprisingly decreased to 0.135%, an 18.2 fold decrease overthe delivery exhibited by Formulation 4.

[0270] It is also evident from this Example that there is a synergisticeffect on the permeation of hydrophobic benefit agents in combinationwith cationic agents and water-soluble silicones. Formulations thatcontain either a cationic agent alone or a siliconeagent alone did notachieve the desired effect of enhanced permeation of the benefit agent.This Example showed that the combination of two or more cationic agentswith one or more water soluble silicone agents was superior with respectto permeation of hydrophobic actives into the skin.

[0271] The amount of salicylic acid penetrated into the skin (epidermisand dermis) after topical application of the Formulations is set forthin Table 24, wherein the formulations were prepared in accordance withthe procedure set forth above. TABLE 24 Levels of salicylic acid in theskin after topical application of various shampoo formulations.Epidermis Dermis Total Skin Delivery Formulation Amt/Surface PercentageAmt/Surface Amt/Surface Percentage Number Area of Applied AreaPercentage of Area of Applied tested (μg/cm²) Dose % (μg/cm²) AppliedDose % (μg/cm²) Dose % #4 11.50 ± 5.07  1.508 ± 0.664 0.412 ± 0.2220.054 ± 0.029 11.912 1.562 #6 4.83 ± 2.52 0.604 ± 0.315 0.195 ± 0.1410.024 ± 0.018 5.027 0.629 #3 9.67 ± 5.61 1.326 ± 0.769 0.419 ± 0.1700.057 ± 0.023 10.093 1.383 #1 5.23 ± 1.27 0.675 ± 0.293 0.473 ± 0.2000.061 ± 0.026 5.707 0.700 #7 2.36 ± 0.37 0.303 ± 0.048 0.137 ± 0.0280.018 ± 0.004 2.493 0.321 #8 0.93 ± 0.20 0.118 ± 0.025 0.022 ± 0.0220.003 ± 0.003 0.95 0.121

[0272] TABLE 25 Statistical significance of salicylic acid permeation asrepresented by p-values determined by the Student's t-test*.Formulations Epidermis Dermis 4 Vs. 6 One Tail = 0.011 One Tail = 0 TwoTail = 0.021 Two Tail = 0 4 Vs. 3 One Tail = 0.373 One Tail = 0 Two Tail= 0.746 Two Tail = 0 4 Vs. 1 One Tail = 0.066 One Tail = 0 Two Tail =0.132 Two Tail = 0

[0273] The results of Table 24 are summarized below in Table 26. TABLE26 Ranking (from best to worst) of the formulations with respect tosalicylic acid delivery into the skin (epidermis and dermis).. Total %Ranking Best Number of Number Of of Salcyclic acid to Worst CationicAgents Silicones Delivered into the Skin 4 3 2 1.562 3 2 1 1.383 1 2 00.700 6 0 0 0.629 7 0 1 0.321 8 0 2 0.121

[0274] It is evident from Tables 24 and 26 above that Formulation 4,which contained a cleansing base incorporated with three cationic agentsand two water-soluble silicones agents (Example 4), delivered thehighest levels of salicylic acid into the skin. It is further evidentthat in the formulation containing only silicone agents incorporatedwith the cleansing base (Example 7 and 8), the level of salicylic aciddelivered into the skin was comparatively low. Notably, the cleansingbase without the cationic agents and silicone agents (Example 6)possessed superior salicylic acid delivery capabilities in comparisonwith formulations containing only silicone agents (Example 7 and 8).Formulation 4, which contained both cationic agents and silicone agents,performed 4.9 times better than formulations without cationic agents(Example 6) and 1.62 times better than formulations containing onlycationic agents (Example 1).

[0275] This example demonstrated that the combination of elubiol andsalicylic acid in a cleansing shampoo with 2 or more cationic agents and1 or water soluble silicone agents performed superior with respect todelivering the elubiol and salicylic acid into the skin. Thus, thecomposition of this invention affords a method of regulating thedelivery of both hydrophobic and hydrophilic actives into the skin.

We claim:
 1. A cleansing composition comprised of: a) at least one watersoluble silicone agent; b) at least one cationic conditioning agent; andc) at least one detergent.
 2. The composition of claim 1 wherein thewater soluble silicone agents are selected from water solubledimethicones substituted with fatty acid moieties, water solublesilicone quaterniums, and mixtures thereof.
 3. The composition of claim1 wherein the dimethicones are substituted with fatty acid moietiesselected from fatty acids having from about 5 carbon atoms to about 30carbon atoms and the silicone quaterniums contain about 6 carbon atomsto about 20 carbon atoms.
 4. The composition of claim 1 wherein thewater soluble volatile silicone agents are selected from the groupconsisting of polydimethylsiloxane, hexamethyldisiloxane, cyclomethiconefluids, and mixtures thereof.
 5. The composition of claim 1 wherein thewater soluble non-volatile silicone agents are selected from the groupconsisting of cetyl triethylmonium dimethicone copolyol phthalate,stearalkonium dimethicone copolyol phthalate, dimethicone copolyolhaving the following structure:

Wherein: q′ is an integer from about 1 to about 7000; q″ is an integerfrom about 1 to about 5000; R₉ may be any water soluble group such as:a) a fatty alcohol having from about 8 carbon atoms to about 30 carbonatoms; b) a fatty acid having from about 8 carbon atoms to about 30carbon atoms, and derivatives thereof; c) a crosslinked water solublepolymer such as mercaptol propyl copolymer; d) a cationic moiety, e.g.trimonium chloride; e) propyl PG-Betaine; f) polypeptides such aspolysarcosine, and e) mixtures thereof, dimethicone copolyol acetate,dimethicone copolyol lactate, dimethicone copolyol laurate, dimethiconecopolyol methyl ether, dimethicone copolyol octyl dodecyl citrate,hydrolyzed soy protein/dimethicone copolyol acetate, dimethiconol, andmixtures thereof.
 6. The composition of claim 2 wherein the watersoluble silicone quaterniums are selected from the group consisting ofsilicone quaternium 13, silicone quaternium 40, quaternium 80, andmixtures thereof.
 7. The composition of claim 1 wherein the watersoluble silicone agents include silicone quaternium 13, cetyltriethylmonium dimethicone copolyol phthalate, stearalkonium dimethiconecopolyol phthalate, and mixtures thereof.
 8. The composition of claim 1comprised of, based upon the total weight of the composition, a) fromabout 0.001 percent to about 20 percent of water soluble siliconeagents; b) from about 0.01 percent to about 10 percent of cationicconditioning agents; and c) from about 0.01 percent to about 30 percentof detergent.
 9. The composition of claim 1 comprised of, based upon thetotal weight of the composition, a) from about 0.01 percent to about 5percent of water soluble silicone agents; b) from about 0.1 percent toabout 5 percent of cationic conditioning agents; and c) from about 5percent to about 20 percent of detergent.
 10. The composition of claim 1wherein the cationic conditioning agent is selected from the groupconsisting of a cationic cellulose derivative; a cationic guarderivative; a homopolymer or copolymer of a cationic monomer selectedfrom: a. a monomer having the formula

wherein R is H or CH₃, Y is O or NH, R₁ is an alkylene group having fromabout 2 to about 6 carbon atoms, R₂, R₃ and R₄ are each independently analkyl group or hydroxyalkyl group having from about 1 to about 22 carbonatoms, and X is a monovalent anion selected from halide and alkylsulfate having from about 1 to about 4 carbon atoms, or b.diallyldimethylammonium chloride, and mixtures thereof.
 11. Thecomposition of claim 10 wherein the cationic conditioning agent isselected from the group consisting of polyquaternium-10, guarhydroxypropyltrimonium chloride, compounds derived from acrylamidopropyltrimonium chloride/acrylamide copolymer, polyquaternium-6,polyquaternium-7, polyquaternium-47, and mixtures thereof.
 12. Thecomposition of claim 11 wherein the cationic conditioning agent isselected from the group consisting of acrylamidopropyltrimoniumchloride/acrylamide copolymer, guar hydroxypropyltrimonium chloride, andmixtures thereof.
 13. The composition of claim 1 wherein the detergentis a surfactant, soap, or mixture thereof.
 14. The composition of claim1 wherein the surfactant is comprised of at least one anionicsurfactant.
 15. The composition of claim 1 wherein the detergent iscomprised of, based upon the total weight of the detergent, a) fromabout 1 percent to about 20 percent of an anionic surfactant; b) fromabout 1 percent to about 10 percent of an amphoteric surfactant; c) fromabout 0 percent to about 4 percent of a cationic surfactant; and d) fromabout 1 percent to about 7 percent of a nonionic surfactant.
 16. Thecomposition of claim 1 wherein the detergent is comprised of, based uponthe total weight of the detergent, a) from about 80 percent to about 95percent of an anionic surfactant selected from the group consisting ofalkyl sulfates, alkyl ether sulfates, and mixtures thereof wherein thealkyl groups have from about 8 carbon atoms to about 18 carbon atoms;and b) from about 5 percent to about 15 percent of an amphotericsurfactant containing at least a cocamidopropyl betaine.
 17. Thecomposition of claim 1 wherein the detergent is comprised of, based uponthe total weight of the detergent, a) from about 70 percent to about 90percent of an anionic surfactant selected from the group consisting ofsodium PEG-7 olive oil carboxylate, alkyl sulfates, alkyl ethersulfates, and mixtures thereof wherein the alkyl group has from about 8carbon atoms to about 18 carbon atoms; b) from about 10 percent to about25 percent of an amphoteric surfactant containing at least acocamidopropyl betaine; and c) from about 2 percent to about 10 percentof a cationic surfactant.
 18. The composition of claim 1 furthercomprising at least one benefit agent.
 19. The composition of claim 18wherein the benefit agent is selected from the group consisting ofelubiol, 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide, shale oil andderivatives thereof, finasteride, ketoconazole, salicylic acid, zincpyrithione, coal tar, benzoyl peroxide, selenium sulfide,hydrocortisone, sulfur, menthol, pramoxine hydrochloride,tricetylammonium chloride, polyquaternium 10, panthenol, panthenoltriacetate, vitamin A and derivatives thereof, vitamin B and derivativesthereof, vitamin C and derivatives thereof, vitamin D and derivativesthereof, vitamin E and derivatives thereof, vitamin K and derivativesthereof, keratin, lysine, arginine, hydrolyzed wheat proteins,hydrolyzed silk proteins, octyl methoxycinnamate, oxybenzone, minoxidil,titanium dioxide, zinc dioxide, retinol, erthromycin, tretinoin, andmixtures thereof.
 20. The composition of claim 18 further comprising,based upon the total weight of the composition, from about 0.001 percentto about 20 percent of the benefit agent
 21. The composition of claim 18further comprising a suspending agent.
 22. The composition of claim 21wherein the composition is comprised of, based upon the total weight ofthe composition, from about 0.01 percent to about 5 percent of thesuspending agent.
 23. The composition of claim 21 wherein the suspendingagent is selected from the group consisting of carbomer, hydroxyethylcellulose, methylvinylether/maleic anhydride copolymer crosslinked with1,9-decadiene PolyVM/MA (PVM/MA decadiene crosspolymer),Acrylates/Aminoacrylates C10-30 Alkyl PEG-20 Itaconate Copolymer, andmixtures thereof.
 24. The composition of claim 1 in the form of ashampoo, a gel, a bath, a cream, a lotion, or a mousse.
 25. The use ofthe composition of claim 1 to cleanse the skin, hair and/or nails.
 26. Adelivery system for delivering benefit agents into and/or onto the hair,nails, and scalp comprised of: a) at least one water soluble siliconeagent; and b) at least one cationic conditioning agent.
 27. The deliverysystem of claim 26 wherein the delivery system is comprised of, basedupon the total weight of the delivery system: a) from about 0.001percent to about 10 of at least one water soluble silicone agent; and b)from about 0.001 percent to about 5 percent of at least one cationicconditioning compounds.
 28. The delivery system of claim 26 wherein thewater soluble silicone agent contains at least a silicone quaternium-13,a cetyl triethylmonium dimethicone copolyol phthalate, or a mixturethereof and the cationic conditioning agent contains at least a guarhydroxypropyltrimonium chloride, an acrylaminopropyltrimoniumchloride/acrylamide copolymer, or a mixture thereof.
 29. A method forenhancing the deposition of benefit agents which comprises topicallyadministering to a human or animal a composition comprised of: a) adelivery system comprised of i) at least two cationic conditioningcompounds selected from the group consisting of guarhydroxypropyltrimonium chloride, acrylaminopropyltrimoniumchloride/acrylamide copolymer, and mixtures thereof; ii) at least onewater soluble silicone compound comprised of silicone quaternium-13; andb) an effective amount of a benefit agent to a desired location on theskin, hair, and/or nails.
 30. The method of claim 29 wherein the benefitagent is elubiol, shale oil and derivatives thereof,6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide, finasteride,ketoconazole, salicylic acid, zinc pyrithione, coal tar, benzoylperoxide, selenium sulfide, hydrocortisone, sulfur, menthol, pramoxinehydrochloride, tricetylammonium chloride, polyquaternium 10, panthenol,panthenol triacetate, vitamin A and derivatives thereof, vitamin B andderivatives thereof, vitamin C and derivatives thereof, vitamin D andderivatives thereof, vitamin E and derivatives thereof, vitamin K andderivatives thereof, keratin, lysine, arginine, hydrolyzed wheatproteins, hydrolyzed silk proteins, octyl methoxycinnamate, oxybenzone,minoxidil, titanium dioxide, zinc dioxide, retinol, erthromycin,tretinoin, and mixtures thereof.
 31. The method of claim 29 wherein thecomposition is further comprised of a detergent.
 32. A method fordepositing a thin coating of conditioner on a hair fiber, comprised of:a) topically applying an effective amount of a delivery systemcomposition comprised of i) at least two cationic conditioning compoundsselected from the group consisting of guar hydroxypropyltrimoniumchloride, acrylaminopropyltrimonium chloride/acrylamide copolymer, andmixtures thereof; ii) at least one water soluble silicone compoundcomprised of cetyl triethylmonium dimethicone copolyol phthalate; andiii) a hydrophilic benefit agent to a desired location on the hair of ahuman or animal.
 33. A method for treating hair loss comprisingtopically administering to a human or animal at a desired area fortreating hair loss a composition comprised of, based upon the totalweight of the composition,: A. a delivery system comprised of i.) atleast one water soluble silicone agent; ii) at least one cationicconditioning agent; and B. an effective amount of a hair loss treatmentagent.
 34. The method of claim 33 wherein the composition is furthercomprised of a detergent.
 35. The method of claim 33 wherein the hairloss treatment agent is selected from minoxidil,N″-cyano-N-(tert-pentyl)-N′-3-pyridinyl-guanidine, diazoxide, vitamin E,vitamin C, vitamin E acetate, vitamin C palmitate; erythropoietin;prostaglandin E1, prostaglandin F2-alpha; oleic acid; heat shock protein27 (“HSP 27”), heat shock protein 72 (“HSP 72”); verapamil HCL,nifedipine, diltiazemamiloride, cyclosporin, Fk-506; finasteride,17-beta estradiol, EGF, FGF, benoxaprofen, tretinoin, IL-6, IL-1alpha,and IL-1 beta ICAM, betametasone, aloe, clove, ginseng, rehmannia,swertia, sweet orange, zanthoxylum, elubiol, ketoconazole, zincpyrithione; streptomycin; cycloheximide; or mixtures thereof.
 36. Themethod of claim 33 wherein the hair loss treatment agent is6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide,N″-cyano-N-(tert-pentyl)-N′-3-pyridinyl-guanidine, a retinoid andderivatives thereof, finasteride, minoxidil, ketoconazole, or mixturesthereof.
 37. The method of claim 33 wherein the hair loss treatmentagent is present in an amount, based upon the total weight of thecomposition, from about 0.001 percent to about 20 percent.
 38. A methodfor inhibiting hair growth comprising topically administering to a humanor animal at a desired area for inhibiting hair growth a compositioncomprised of, based upon the total weight of the composition,: A. adelivery system comprised of i.) at least one water soluble siliconeagent; ii) at least one cationic conditioning agent; and B. an effectiveamount of a hair growth inhibiting agent.
 39. The method of claim 38wherein the hair growth inhibiting agent is selected from antineoplasitcagents; anticoagulants; antithyroid drugs; lithium; lithium carbonate;interferons; retinoids; antihyperlipidaemic drugs; thallium; mercury;albendazole; allopurinol; amiodarone; amphetamines; androgens;bromocriptine; butyrophenones; carbamazepine; cholestyramine;cimetidine; clofibrate; danazol; desipramine; dixyrazine; ethambutol;etionamide; fluoxetine; gentamicin; gold salts; hydantoins; ibuprofen;impramine; immunoglobulins; indandiones; indomethacin; intraconazole;levadopa; maprotiline; methysergide; metoprolol, metyrapone; nadolol;nicotinic acid; potassium thiocyanate; propranolol, pyridostimine;salicylates; sulfasalazine; terfenadine; thiamphenicol; thiouracils;trimethadione; troparanol; valproic acid or mixtures thereof.
 40. Themethod of claim 38 wherein the hair growth inhibiting agent is a serineprotease, retinol, isotretinoin, betamethisone, alpha-tocophenol andderivatives thereof, or a mixture thereof.
 41. The method of claim 38wherein the hair growth inhibiting agent is present in an amount, basedupon the total weight of the composition, from about 0.001 percent toabout 20 percent.
 42. The method of claim 38 further comprising adetergent.
 43. A method for treating or minimizing the effects of agingcomprising topically administering to a human or animal at a desiredarea a composition comprised of, based upon the total weight of thecomposition,: A. a delivery system comprised of i.) at least one watersoluble silicone agent; ii) at least one cationic conditioning agent;and B. an effective amount of an anti-aging active agent.
 44. The methodof claim 43 wherein the anti-aging active agent is selected fromsunscreens; retinoids and derivatives thereof; vitamins and derivativesthereof; antioxidants; hydrocarboxy acids; botanical extracts; ormixtures thereof.
 45. The method of claim 43 wherein the anti-agingactive agent is retinol, tretinoin, or mixtures thereof.
 46. The methodof claim 43 wherein the anti-aging active agent is present in an amount,based upon the total weight of the composition, from about 0.01 percentto about 10 percent.
 47. The method of claim 43 wherein the compositionis further comprised of a detergent.
 48. A method for treating acnecomprising topically administering to a human or animal at a desiredarea a composition comprised of, based upon the total weight of thecomposition,: A. a delivery system comprised of i.) at least one watersoluble silicone agent; ii) at least one cationic conditioning agent;and B. an effective amount of an anti-acne active agent.
 49. The methodof claim 48 wherein the anti-acne active agent is selected fromimidazoles; retinoids; salicylic acid; benzoyl peroxide; antibiotics;antiandrogens; 5-alpha-reductase isotypes; anti-inflammatory agents;botanical extracts; or mixtures thereof.
 50. The method of claim 48wherein the anti-acne active agent is retinol, elubiol, an antibiotic,salicylic acid or mixtures thereof.
 51. The method of claim 48 whereinthe anti-acne active agent is present in an amount, based upon the totalweight of the composition, from about 0.01 percent to about 10 percent.52. The method of claim 48 wherein composition is further comprised of adetergent.
 53. A method for depigmenting skin comprising topicallyadministering to a human or animal at a desired area a compositioncomprised of, based upon the total weight of the composition,: A. adelivery system comprised of i.) at least one water soluble siliconeagent; ii) at least one cationic conditioning agent; and B. an effectiveamount of a depigmentation active agent.
 54. The method of claim 53wherein the depigmentation active agent is selected from retinoids andderivatives thereof; kojic acid and its derivatives; hydroquinone andderivatives thereof; transexamic acid; vitamins; azelaic acid; botanicalextracts or mixtures thereof.
 55. The method of claim 53 wherein thedepigmentation active agent is kojic acid, retinol, hydroquinone,transexamic acid or mixtures thereof.
 56. The method of claim 53 whereinthe depigmentation active agent is present in an amount, based upon thetotal weight of the composition, from about 0.01 percent to about 10percent.
 57. The method of claim 53 wherein the composition is furthercomprised of a detergent.
 58. A method for treating the diseases ofdandruff, seborrheic dermatitis, and psoriasis and/or the symptomsassociated therewith comprising topically administering to a human oranimal at a desired area a composition comprised of, based upon thetotal weight of the composition,: A. a delivery system comprised of i.)at least one water soluble silicone agent; ii) at least one cationicconditioning agent; and B. an effective amount of a benefit agentselected from the group consisting of an anti-dandruff agent, ananti-seborrheic dermatitis agent, an anti-psoriasis agent, and mixturesthereof.
 59. The method of claim 58 wherein the anti-dandruff agent, theanti-seborrheic dermatitis agent, and the anti-psoriasis agent areselected from zinc pyrithione, selenium sulfide, sulfur; sulfonatedshale oil; salicylic acid; coal tar; povidone-iodine, imidazoles such asketoconazole, dichlorophenyl imidazolodioxalan, clotrimazole,itraconazole, miconazole, climbazole, tioconazole, sulconazole,butoconazole, fluconazole, miconazolenitrite and any possible stereoisomers and derivatives thereof such as anthralin; piroctone olamine(Octopirox); selenium sulfide; ciclopirox olamine; anti-psoriasisagents; vitamin A analogs; corticosteroids and mixtures thereof.
 60. Themethod of claim 58 wherein the anti-dandruff agent, the anti-seborrheicdermatitis agent, and the anti-psoriasis agent are selected fromelubiol, ketoconazole, coal tar, salicylic acid, zinc pyrithione,selenium sulfide, hydrocortisone, sulfur, menthol, pramoxinehydrochloride and mixtures thereof.
 61. The method of claim 58 whereinthe anti-dandruff agent, the anti-seborrheic dermatitis agent, and theanti-psoriasis agent are present in an amount, based upon the totalweight of the composition, from about 0.001 percent to about 10 percent.62. The method of claim 58 wherein the composition is further comprisedof a detergent.